1966-65-0

Basic information

• Product Name: 1-PHENYL-4-METHYL-1-PENTYN-3-OL
• Synonyms: TIMTEC-BB SBB008968;TIMTEC-BB SBB008969;1-PHENYL-4-METHYL-1-PENTYN-3-OL;1-PHENYL-3-METHYL-1-PENTYN-3-OL;4-METHYL-1-PHENYL-PENT-1-YN-3-OL;4-METHYL-1-PHENYL-1-PENTYN-3-OL;3-METHYL-1-PHENYL-1-PENTYN-3-OL;3-methyl-1-phenylpent-1-yn-3-ol
• CAS NO: 1966-65-0
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.24
• EINECS: 217-814-9
• Mol File: 1966-65-0.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 277°Cat760mmHg
• Flash Point: 123.9°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.00224mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: 1-PHENYL-4-METHYL-1-PENTYN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-4-METHYL-1-PENTYN-3-OL(1966-65-0)
• EPA Substance Registry System: 1-PHENYL-4-METHYL-1-PENTYN-3-OL(1966-65-0)

Safety Data

• Hazardous Substances Data: 1966-65-0(Hazardous Substances Data)

Usage

General Description

1-PHENYL-4-METHYL-1-PENTYN-3-OL is a chemical compound with the molecular formula C12H14O. It is a colorless liquid that is used in organic synthesis as a reagent for the preparation of various other chemical compounds. It is known for its ability to undergo reactions such as oxidation, reduction, and addition, making it versatile in terms of its synthetic applications. 1-PHENYL-4-METHYL-1-PENTYN-3-OL is also used in the pharmaceutical industry as an intermediate for the production of various drugs and pharmaceuticals. Additionally, it has potential applications in the field of materials science, such as in the production of polymers and other advanced materials.

InChI:InChI=1/C12H14O/c1-10(2)12(13)9-8-11-6-4-3-5-7-11/h3-7,10,12-13H,1-2H3

Upstream product

• 591-50-4 iodobenzene 
• 77-75-8 meparfynol 
• 6804-29-1 1-Phenylaethinyl-1-<2-hydroxyaethoxy>-cyclopentan 
• 6738-06-3 phenylethynylmagnesium bromide 
• 78-93-3 butanone 
• 536-74-3 phenylacetylene 
• 19307-74-5 1-phenyl-pent-1-yn-3-one 

Downstream Products

• 536-74-3 phenylacetylene 
• 78-93-3 butanone 
• 111679-80-2 1-(4-methylhexa-2,3-dien-2-yl)benzene 
• 1586814-80-3 2,2-dichloro-3-hydroxy-3-methyl-1-phenylpentan-1-one 
• 1586814-72-3 2,2-dibromo-3-hydroxy-3-methyl-1-phenylpentan-1-one 
• 1515868-42-4 μ-η2-(3-methoxy-3-methyl-1-phenyl-1-pentyne)dicobalthexacarbonyl 
• 1515868-43-5 μ-η2-(3-methyl-1-phenyl-1-pentyne)dicobalthexacarbonyl 
• 1515868-41-3 μ-η2-(3-methyl-1-phenyl-1-pentyn-3-ol)dicobalthexacarbonyl 
• 40036-62-2 (3-methylpent-1-ynyl)benzene 

Relevant articles and documents

Dual Palladium/Copper-Catalyzed anti-Selective Intermolecular Allenylsilylation of Terminal Alkynes: Entry to (E)-Silyl Enallenes

A palladium-/copper-cocatalyzed three-component trans-allenylsilylation of terminal alkynes with propargyl acetates and PhMe2SiBpin is described, which is driven by the regioselective allenylation of the alkyne with propargyl acetates and then silylation. This method allows the simultaneous incorporation of an allene and silicon across the CC bond and provides a highly chemo-, regio-, and stereoselective alkyne difunctionalization route to the synthesis of valuable (E)-silyl enallenes. The utility of this method is highlighted by late-stage derivatization of bioactive compounds.

Benzene-1,3,5-triyl Triformate (TFBen)-Promoted Palladium-Catalyzed Carbonylative Synthesis of 2-Oxo-2,5-dihydropyrroles from Propargyl Amines

In this letter, we developed a palladium-catalyzed procedure for the cyclocarbonylation of propargyl amines. Benzene-1,3,5-triyl triformate (TFBen) has been explored as the CO source and also as the key promotor. Various substituted 2-oxo-dihydropyrroles were produced in a facile manner in good yields (up to 90%).

Flow rhodaelectro-catalyzed alkyne annulations by versatile C-H Activation: Mechanistic support for rhodium(III/IV)

A flow-metallaelectro-catalyzed C-H activation was realized in terms of robust rhodaelectro-catalyzed alkyne annulations. To this end, a modular electro-flow cell with a porous graphite felt anode was designed to ensure efficient turnover. Thereby, a variety of C-H/N-H functionalizations proved amenable for alkyne annulations with high levels of regioselectivity and functional group tolerance, viable in both an inter- or intramolecular manner. The electro-flow C-H activation allowed easy scale up, while in-operando kinetic analysis was accomplished by online flow-NMR spectroscopy. Mechanistic studies suggest an oxidatively induced reductive elimination pathway on rhodium(III) in an electrocatalytic regime.