77-75-8 Usage
Description
3-Methyl-1-pentyn-3-ol, also known as 3-Methylpent-1-yn-3-ol, is a clear slightly yellow liquid or low melting solid with a unique chemical structure. It is an organic compound that possesses various functional groups, making it versatile for different applications across various industries.
Uses
Used in High-Insulation Solvent-Free Silicone Resin for Composite Insulators:
3-Methyl-1-pentyn-3-ol is used as an inhibitor in the method for preparing high-insulation solvent-free silicone resin for composite insulators. Its role as an inhibitor helps enhance the insulation properties and overall performance of the silicone resin, making it suitable for use in composite insulators.
Used in Chlorinated Solvents:
In the chlorinated solvents industry, 3-Methyl-1-pentyn-3-ol is utilized as a stabilizer. It helps maintain the stability and longevity of the solvents, ensuring their effectiveness and safety during use.
Used as a Viscosity Reducer:
3-Methyl-1-pentyn-3-ol is employed as a viscosity reducer in various applications, where it helps lower the viscosity of liquids, making them easier to handle and process.
Used as an Electroplating Brightener:
In the electroplating industry, 3-Methyl-1-pentyn-3-ol is used as a brightener to improve the appearance and quality of the electroplated surfaces.
Used as an Intermediate in Synthesis:
3-Methyl-1-pentyn-3-ol serves as an intermediate in the synthesis of hypnotics and isoprenoid chemicals, contributing to the development of pharmaceuticals and other related compounds.
Used as a Solvent for Polyamide Resins:
3-Methyl-1-pentyn-3-ol is also used as a solvent for polyamide resins, which are essential in the production of various plastics and materials with specific properties.
Used as an Acid Inhibitor:
3-Methyl-1-pentyn-3-ol is utilized as an acid inhibitor in different applications, where it helps prevent the formation of acids that could cause corrosion or other undesirable effects.
Used for Prevention of Hydrogen Embrittlement:
In the field of materials science, 3-Methyl-1-pentyn-3-ol is used to prevent hydrogen embrittlement, a phenomenon that can lead to the failure of metals and alloys under stress.
Used in Medicine:
3-Methyl-1-pentyn-3-ol is also used in the medical field, particularly as a soporific (sleep-inducing) and anesthetic agent, thanks to its ability to induce sedation and reduce the sensation of pain.
Originator
Citodorm,Haury
Manufacturing Process
To 5 parts of sodium acetylene in absolute ether 6 parts of dry methyl ethyl ketone was slowly dropwise added with ice cooling and stirring. Than the reaction mixture was poured into excess of acetic acid by ice cooling and extracted with ether. The ether extract was washed with solution of potash for removing the diluted acetic acid and dried over potassium carbonate. The ether was distilled off and residual colorless oil methylpentynol had BP at 120°-121°C. Instead of sodium acetylene the solution of sodium acetylene in liquid ammonia may be successfully used.
Therapeutic Function
Sedative
Check Digit Verification of cas no
The CAS Registry Mumber 77-75-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77-75:
(4*7)+(3*7)+(2*7)+(1*5)=68
68 % 10 = 8
So 77-75-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H10O/c1-4-6(3,7)5-2/h1,7H,5H2,2-3H3/t6-/m0/s1
77-75-8Relevant articles and documents
Expedient synthesis of quadrilure antipodes, the pheromone of square-necked grain beetle
Pawar,Chattopadhyay
, p. 463 - 468 (1995)
Both the enantiomers of the title pheromone, (E)-3-methyl-7-acetoxynon-3-ene (I) have been synthesized in high enantiomeric excess via a stereoselective route. Thus, easily accessible, 3-methylpent-1-en-3-ol (2) was converted via a Claisen orthoester rearrangement to the ester (3) with exclusive (E)-geometry. Its derivatization to the aldehyde (5) followed by reaction with ethylmagnesium bromide gave the racemic pheromone alcohol (6) in 27.7% overall yield. Its enantioselective lipase catalyzed trans-esterification directly afforded (R)-I, while its antipode was obtained from the resolved alcohol by chemical acetylation.
Alkynylation of aldehydes and ketones using the Bu4NOH/H 2O/DMSO catalytic composition: A wide-scope methodology
Schmidt, Elena Yu.,Cherimichkina, Natalia A.,Bidusenko, Ivan A.,Protzuk, Nadezhda I.,Trofimov, Boris A.
, p. 4663 - 4670 (2014/08/05)
The Favorsky reaction of a wide range of aldehydes and ketones with alkynes has been implemented under mild conditions (5-20 C). Using a Bu 4NOH/H2O/DMSO catalytic system, propargylic alcohols are formed cleanly in 39-93% (mostly 72-93%) yields and with ca. 100% selectivity. The method is suitable for aliphatic, aromatic, and heteroaromatic aldehydes and ketones, and for aliphatic, aromatic, and functionalized acetylenes. Thus, this represents the most general and efficient protocol to achieve the Favorsky reaction. Copyright
Stereoselective One-Pot synthesis of 1-Aminoindanes and 5,6-Fused azacycles using a Gold-Catalyzed Redox-Pinacol-Mannich-Michael cascade
Yeom, Hyun-Suk,Lee, Youngun,Jeong, Jaewon,So, Eunsoo,Hwang, Soojin,Lee, Ji-Eun,Lee, Shim Sung,Shin, Seunghoon
supporting information; experimental part, p. 1611 - 1614 (2010/06/15)
"Chemical Equation Presented" Just another Mannich Monday: A cascade intramolecular redox-pinacol-Mannich-Michael reaction sequence catalyzed by gold complexes can be used to generate a variety of structures including spirocycles, 1-aminoindanes, and 5,6-fused azabicycles that have a quaternary carbon center. The reaction is characterized by complete atom-economy, high diastereoselectivity, and remarkable efficiency through tandem reactions.