197163-72-7

Basic information

• Product Name: 4-n-butyl-2-phenylquinazoline
• Synonyms: 4-n-butyl-2-phenylquinazoline
• CAS NO: 197163-72-7
• Molecular Weight: 262.354
• Mol File: 197163-72-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 4-n-butyl-2-phenylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-n-butyl-2-phenylquinazoline(197163-72-7)
• EPA Substance Registry System: 4-n-butyl-2-phenylquinazoline(197163-72-7)

Safety Data

• Hazardous Substances Data: 197163-72-7(Hazardous Substances Data)

Upstream product

• 110-59-8 pentanonitrile 
• 58109-40-3 diphenyliodonium hexafluorophosphate 
• 100-47-0 benzonitrile 
• 100-52-7 benzaldehyde 
• 1885-29-6 anthranilic acid nitrile 
• 5589-62-8 2-(benzylamino)benzonitrile 
• 16659-09-9 1-phenylbutylideneamine 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 103-82-2 phenylacetic acid 
• 61485-11-8 1-(2-aminophenyl)pentan-1-one 
• 6484-25-9 4-chloro-2-phenylquinazoline 
• 1116-70-7 tri(n-butyl)aluminium 
• 108-88-3 toluene 
• 613-92-3 N-hydroxyl-benzamidine 

Relevant articles and documents

Synthesis of Quinazolines via an Iron-Catalyzed Oxidative Amination of N-H Ketimines

An efficient synthesis of quinazolines based on an iron-catalyzed C(sp3)-H oxidation and intramolecular C-N bond formation using tert-BuOOH as the terminal oxidant is described. The reaction of readily available 2-alkylamino benzonitriles with various organometallic reagents led to 2-alkylamino N-H ketimine species. The FeCl2-catalyzed C(sp3)-H oxidation of the alkyl group employing tert-BuOOH followed by intramolecular C-N bond formation and aromatization afforded a wide variety of 2,4-disubstituted quinazolines in good to excellent yields.

2-subsituted quinazoline preparation method

The present invention discloses a 2-subsituted quinazoline preparation method, in particular, 2-subsituted quinazoline is obtained by oxidative decarboxylation and condensation oxidation reaction of o-amino phenyl ketone, an aryl acetic acid and an inorga

General copper-catalyzed coupling of alkyl-, aryl-, and alkynylaluminum reagents with organohalides

We report the first example of a very general Cu-catalyzed cross-coupling of organoaluminum reagents with organohalides. The reactions proceed for the couplings of alkyl-, aryl-, and alkynylaluminum reagents with aryl and heteroaryl halides and vinyl bromides, affording the cross-coupled products in good to excellent yields. Both primary and secondary alkylaluminum reagents can be utilized as organometallic coupling partners. These reactions are not complicated by β-hydride elimination, and as a result rearranged products are not observed with secondary alkylaluminum reagents even for couplings with heteroaryl halides under "ligand-free" conditions. Radical clock experiment with a radical probe and relative reactivity study of Ph3Al with two haloarenes, 1-bromonaphthalene and 4-chlorobenzonitrile, having two different redox potentials indicates that the reaction does not involve free aryl radicals and radical anions as intermediates. These results combined with the result of the Hammett plot obtained by reacting Ph3Al with iodoarenes containing p-H, p-Me, p-F, and p-CF3 substituents, which shows a linear curve (R2 = 0.99) with a ρ value of +1.06, suggest that the current transformation follows an oxidative addition-reductive elimination pathway.