197297-77-1Relevant articles and documents
Highly stereoselective construction of the C2 stereocentre of α-tocopherol (Vitamin E) by asymmetric addition of Grignard reagents to ketones
Bieszczad, Bartosz,Gilheany, Declan G.
, p. 6483 - 6492 (2017/08/16)
Tertiary alcohol precursors of both C2 diastereoisomers of α-tocopherol were prepared in three ways by our recently reported asymmetric Grignard synthesis. The versatility of Grignard chemistry inherent in its three-way disconnection was exploited to allow the synthesis of three product grades: 77:23 dr (5 steps), 81:19 dr (5 steps) and 96:4 dr (7 steps, one gram scale) from readily available and abundant starting materials. The products were converted to their respective α-tocopherols in 3 steps, which allowed a definitive re-assignment of their absolute configurations.
Preparation of Enantiopure Precursors for the Vitamin E Synthesis. A Comparison of the Asymmetric Allylation of Ketones and the Sharpless Bishydroxylation
Tietze, Lutz F.,G?rlitzer, Jochen
, p. 1049 - 1050 (2007/10/03)
The enantioselective synthesis of the precursors 9, 10, 16 and 17 for the preparation of enantiopure vitamin E by asymmetric allylation of the ketone 6 and Sharpless bishydroxylation of the aliphatic alkenes 11 and 15 is described.