197508-63-7Relevant articles and documents
Synthesis of a radioactive photoaffinity arachidonic acid analog
Perrier, Helene,Prasit, Petpiboon,Wang, Zhaoyin
, p. 1501 - 1502 (1994)
A novel photoaffinity probe based of arachidonic acid was synthesized by coupling 20-hydroxyarachidonic acid and 2-azido-5-iodobenzoic acid. The key epoxide required for the formation of 20-hydroxyarachidonic acid was obtained using a new mild and safe me
Synthesis of 15N-, 13C-, and 2H-labeled methanandamide analogs
Yao, Fen-Mei,Palmer, Sonya L.,Khanolkar, Atmaram D.,Tian, Xiaoyu,Guo, Jianxin,Makriyannis, Alexandros
, p. 115 - 129 (2003)
Four isotopically labeled, metabolically stable analogs of arachidonylethanolamide (anandamide), an endogenous cannabinoid ligand, were synthesized via a five-step reaction sequence starting from arachidonic acid. These stable methanandamide derivatives will serve as probes for studying the conformational properties of anandamide in model membrane systems using solid-state NMR spectroscopy. The synthetic methods described can be applied to the preparations of other anandamide analogs with isotopic labeling in different positions of the molecule, which could be utilized in biochemical and pharmacological experiments. Copyright
SYNTHESIS OF FLUOROARACHIDONIC ACID AND METHODS OF USE THEREOF
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Paragraph 0061, (2013/11/19)
There are provided, inter alia, methods for diagnosis of the extent of neuroinflammation in a subject. The methods include administering an 18F-labeled arachidonic acid to a subject in need thereof, obtaining a positron emission tomography (PET
CANNABINERGIC LIPID LIGANDS
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Page/Page column 38, (2008/06/13)
One aspect of this disclosure relates generally to lipid compounds that exert diverse effects in the endocannabinoid system, such as regulating CB1 and CB2 receptor or moderating other bio-macromolecules within the endocannabinoid system. Some of the compounds showed improved receptor binding affinity, and/or improved receptor subtype selectivity, and improved bio-stability. Some of the compounds exhibit activities to regulate the enzymes that moderate the bio-disposal of endogenous cannabinoids, such as the fatty acid amide hydrolase (FAAH). Some of the compounds exhibit activities to inhibit the anandamide transporter. Other aspects of the invention are pharmaceutical preparations employing these ligands and methods of administering therapeutically effective amounts of the preparations to provide a physiological effect.