71030-37-0 Usage
Description
(+/-)12-HETE, also known as 12-Hydroxyeicosatetraenoic acid, is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. It exhibits similar biological activity to its constituent enantiomers and has the ability to aggregate neutrophils with an EC50 value of 40 nM.
Uses
Used in Pharmaceutical Industry:
(+/-)12-HETE is used as a pharmaceutical agent for its potential role in modulating inflammatory responses and immune system functions. Its ability to aggregate neutrophils makes it a valuable compound for studying the mechanisms of inflammation and immune cell interactions.
Used in Research Applications:
(+/-)12-HETE is used as a research tool for investigating the biological activity and signaling pathways related to arachidonic acid metabolism. It aids in understanding the role of eicosanoids in various physiological and pathological processes, including inflammation, pain, and tissue repair.
Used in Drug Development:
(+/-)12-HETE is utilized in the development of new drugs targeting inflammatory and immune-related disorders. Its unique properties and interactions with immune cells make it a promising candidate for the creation of novel therapeutic agents to treat various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 71030-37-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,0,3 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 71030-37:
(7*7)+(6*1)+(5*0)+(4*3)+(3*0)+(2*3)+(1*7)=80
80 % 10 = 0
So 71030-37-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h6-9,11-12,15,18-19,21H,2-5,10,13-14,16-17H2,1H3,(H,22,23)
71030-37-0Relevant articles and documents
Repurposing Resveratrol and Fluconazole to Modulate Human Cytochrome P450-Mediated Arachidonic Acid Metabolism
El-Sherbeni, Ahmed A.,El-Kadi, Ayman O. S.
, p. 1278 - 1288 (2016/04/26)
Cytochrome P450 (P450) enzymes metabolize arachidonic acid (AA) to several biologically active epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs). Repurposing clinically-approved drugs could provide safe and readily available means
The Total Synthesis of 12-HETE and 12,20-DiHETE
Leblanc, Yves,Fitzsimmons, Brian J.,Adams, Julian,Perez, Francoise,Rokach, Joshua
, p. 789 - 793 (2007/10/02)
The total syntheses of 12-HETE (1) in racemic form and of both enantiomers in optically pure form are reported.The synthesis of a metabolite of 12(S)-HETE, 12,20-diHETE (2), in optically pure form is also reported.
A SHORT, THREE-COMPONENT TOTAL SYNTHESIS OF 12-HYDROXYEICOSA-5,8,14(Z),10(E)-TETRAENOIC ACID (12-HETE) VIA THE CORRESPONDING KETONE
Corey, E. J.,Kyler, Keith,Raju, Natarajan
, p. 5115 - 5118 (2007/10/02)
A highly effective synthesis of (+/-)-12-HETE (1) from the componenets 2, 3, and 6 is desribed which employs a new class of cuprate reagents.
