198007-56-6

Basic information

• Product Name: 5-(7-Azido-heptyl)-1-(6-azido-hexyl)-1H-pyrrole-2-carboxylic acid [(S)-1-(adamantan-1-ylcarbamoyl)-2-(4-tert-butoxy-phenyl)-ethyl]-amide
• CAS NO: 198007-56-6
• Molecular Weight: 727.994
• Mol File: 198007-56-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(7-Azido-heptyl)-1-(6-azido-hexyl)-1H-pyrrole-2-carboxylic acid [(S)-1-(adamantan-1-ylcarbamoyl)-2-(4-tert-butoxy-phenyl)-ethyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(7-Azido-heptyl)-1-(6-azido-hexyl)-1H-pyrrole-2-carboxylic acid [(S)-1-(adamantan-1-ylcarbamoyl)-2-(4-tert-butoxy-phenyl)-ethyl]-amide(198007-56-6)
• EPA Substance Registry System: 5-(7-Azido-heptyl)-1-(6-azido-hexyl)-1H-pyrrole-2-carboxylic acid [(S)-1-(adamantan-1-ylcarbamoyl)-2-(4-tert-butoxy-phenyl)-ethyl]-amide(198007-56-6)

Safety Data

• Hazardous Substances Data: 198007-56-6(Hazardous Substances Data)

Upstream product

• 634-97-9 pyrrole-2-carboxyl acid 
• 198007-52-2 5-[7-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexyl]-1H-pyrrole-2-carboxylic acid methyl ester 
• 198007-51-1 5-[(E)-7-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexyl]-1H-pyrrole-2-carboxylic acid methyl ester 
• 198007-54-4 5-(7-Azido-heptyl)-1-(6-azido-hexyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 198007-44-2 1-[6-(tert-Butyl-dimethyl-silanyloxy)-hexyl]-5-formyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 198007-53-3 5-(7-Hydroxy-heptyl)-1-(6-hydroxy-hexyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 1197-13-3 methyl 5-formyl-1H-pyrrole-2-carboxylate 
• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 194673-22-8 (2S)-N-Adamantyl-2-amino-3-[(4-tert-butoxy)phenyl]propanamide 
• 198007-55-5 1-(6-azidohexyl)-5-(7-azidoheptyl)pyrrole-2-carboxylic acid 

Relevant articles and documents

Design, synthesis and pharmacological evaluation of active pyrrole based, nonpeptidic analogues of neurotensin(8-13)

We report the design, synthesis and pharmacological analysis of pyrrole based, nonpeptidic analogues of neurotensin(8-13) for testing further our reported multiple template approach to developing nonpeptidic mimetics of neuropeptides and for developing nonpeptidic mimetics of neurotensin(8-13) as potential drug candidates for the treatments of neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Three newly synthesized pyrrole analogues (mimics-4, -5 and -6) designed by the multiple template approach have been found to be more active in binding to the neurotensin receptor than the previously reported indole based mimics-1 and -2, which are a partial nonpeptidic antagonist and an agonist of neurotensin(8-13), respectively. The results support the theory of the multiple template approach and provide insights into the rational design of more potent neurotensin mimetics and into the library design for rational screening for effective nonpeptide compounds by combinatorial chemistry.