1197-13-3Relevant articles and documents
Synthesis and characterization of Boc-protected 4-amino- and 5-amino-pyrrole-2-carboxylic acid methyl esters
Chakraborty, Tushar Kanti,Udawant, Sandip P.,Roy, Saumya,Mohan, Bajjuri Krishna,Rao, Kolla Srinivasa,Dutta, Samit Kumar,Kunwar, Ajit Chand
, p. 4631 - 4634 (2006)
Syntheses of Boc-protected 4-amino- and 5-amino-pyrrole-2-carboxylic acid methyl esters have been achieved and the structures of these compounds have been fully characterized by detailed NMR studies.
Discovery of a novel HCV helicase inhibitor by a de novo drug design approach
Kandil, Sahar,Biondaro, Sonia,Vlachakis, Dimitrios,Cummins, Anna-Claire,Coluccia, Antonio,Berry, Colin,Leyssen, Pieter,Neyts, Johan,Brancale, Andrea
, p. 2935 - 2937 (2009)
Herein we report a successful application of a computer-aided design approach to identify a novel HCV helicase inhibitor. A de novo drug design methodology was used to generate an initial set of structures that could potentially bind to a putative binding
The role of N-terminal heterocycles in hydrogen bonding to α-chymotrypsin
Schumann, Nicholas C.,Bruning, John,Marshall, Andrew C.,Abell, Andrew D.
, p. 396 - 399 (2019)
A series of dipeptide aldehydes containing different N-terminal heterocycles was prepared and assayed in vitro against α-chymotrypsin to ascertain the importance of the heterocycle in maintaining a β-strand geometry while also providing a hydrogen bond do
Design, Sustainable Synthesis, and Programmed Reactions of Templated N-Heteroaryl-Fused Vinyl Sultams
Laha, Joydev K.,Sharma, Shubhra,Kirar, Seema,Banerjee, Uttam C.
, p. 9350 - 9359 (2017/09/23)
A de novo design and synthesis of N-heteroaryl-fused vinyl sultams as templates for programming chemical reactions on vinyl sultam periphery or (hetero)aryl ring is described. The key features include rational designing and sustainable synthesis of the template, customized reactions of vinyl sultams at C=C bond or involving N-S bond cleavage, and reactions on the periphery of the heteroaryl ring for late-stage diversification. The simple, easy access to the template coupled with opportunities for the synthesis of diversely functionalized heterocyles from a single template constitutes a rare study in contemporary organic synthesis.
