199336-05-5 Usage
Description
TRANS (1S,2S)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE, also known as N-[(1S,2S)-2-aminocyclohexyl]-Carbamic Acid Phenylmethyl Ester, is an organic compound with a unique structure that features a cyclohexane ring with two amine groups in the 1 and 2 positions. It is characterized by its ability to form carbamic acid esters, which are essential in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
TRANS (1S,2S)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE is used as a reagent for the synthesis of anti-cancer agents, specifically AA005 derivatives. It plays a crucial role in the development of novel cancer treatments by contributing to the chemical structure of these therapeutic compounds.
Additionally, it is used in the preparation of pirenzepine analogs, which are known for their antimuscarinic properties. These analogs have potential applications in the treatment of various conditions, such as gastrointestinal disorders and urinary incontinence, by blocking the action of acetylcholine on muscarinic receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 199336-05-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,3,3 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 199336-05:
(8*1)+(7*9)+(6*9)+(5*3)+(4*3)+(3*6)+(2*0)+(1*5)=175
175 % 10 = 5
So 199336-05-5 is a valid CAS Registry Number.
199336-05-5Relevant articles and documents
Solvent-induced reversal of enantioselectivity in the synthesis of succinimides by the addition of aldehydes to maleimides catalysed by carbamate-monoprotected 1,2-diamines
Flores-Ferrndiz, Jess,Fiser, Bla,Gmez-Bengoa, Enrique,Chinchilla, Rafael
, p. 1218 - 1225 (2015/03/04)
A simple change in the polarity of the solvent allows both enantiomers of substituted succinimides to be obtained in the enantioselective conjugate addition reaction of aldehydes, mainly disubstituted, to maleimides catalysed by chiral carbamate-monoprote
A novel bifunctional sulfonamide primary amine-catalyzed enantioselective conjugate addition of ketones to nitroolefins
Xue, Fei,Zhang, Shilei,Duan, Wenhu,Wang, Wei
supporting information; experimental part, p. 2194 - 2198 (2009/10/02)
The enantioselective conjugate addition of a variety of ketones to nitroolefins has been developed. The process is efficiently catalyzed by a novel bifunctional sulfonamide primary amine in good yields and with good levels of enantioselectivity.
