19969-04-1Relevant articles and documents
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Meyers,Smith
, p. 1084 (1970)
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Efficient Generation and Synthetic Applications of Alkyl-Substituted Siloxycarbenes: Suppression of Norrish-Type Fragmentations of Alkanoylsilanes by Triplet Energy Transfer
Abe, Manabu,Hagiwara, Chihiro,Ishida, Kento,Kusama, Hiroyuki,Yamazaki, Hokuto
supporting information, p. 1249 - 1253 (2020/02/04)
Acylsilanes have been known to undergo isomerization to siloxycarbenes under photoirradiation and the thus generated carbenes can be utilized for various synthetic reactions. But this carbene formation is not necessarily efficient with some alkanoylsilanes because Norrish-type fragmentations compete, which limit the synthetic utility of alkanoylsilanes as carbene precursors. In this study, generation of siloxycarbenes from alkanoylsilanes by visible-light-induced energy transfer was examined by using an Ir complex, [Ir{dF(CF3)ppy}2(dtbpy)]PF6, and was successfully applied to the C?C coupling reactions with boronic esters or aldehydes. This methodology efficiently suppressed undesired Norrish-type reactions and broadened synthetic utility of alkanoylsilanes.
Synthetic method of medical intermediate diaryl ketone compound
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Paragraph 0066; 0067; 0068; 0069; 0070, (2017/04/29)
The invention relates to a synthetic method of a diaryl ketone compound which can be used as a medical intermediate and is as shown in the formula (III). The method comprises the following steps: in an organic solvent and in the presence of a catalyst, an oxidizing agent, an organic ligand and alkali, a compound as shown in the formula (I) and a compound as shown in the formula (II) react; and after the reaction, the reaction product undergoes postprocessing so as to obtain the compound as shown in the formula (III). In the formula (III), R1 is selected from H, C1-C6 alkyl group or C1-C6 alkoxy group; R2 is selected from C1-C6 alkyl group or unsubstituted or phenyl group bearing substituent group, wherein the substituent group is C1-C6 alkyl group or halogen; and X is halogen. According to the method, novel reaction materials and catalytic system are adopted. Through integrated collaboration of multiple characteristics, efficient preparation of the diaryl ketone compound is realized. Sources of materials are widened, and yield of the product is raised. The synthetic method has a wide industrial prospect.