20154-03-4 Usage
Description
3-(Trifluoromethyl)pyrazole is a heterocyclic building block with a colorless to light yellow liquid appearance. It is known for its ability to undergo alkylation with alkyl iodides in DMF, leading to the formation of N-alkyl pyrazoles. Additionally, it participates in the synthesis of disubstituted pyrimidines, showcasing its versatility in chemical reactions.
Uses
Used in Pharmaceutical Industry:
3-(Trifluoromethyl)pyrazole is used as a small compound inhibitor for human FATP2, which plays a crucial role in the absorption and transport of long-chain fatty acids. Its inhibitory properties make it a potential candidate for the development of drugs targeting FATP2-related conditions.
Used in Chemical Synthesis:
3-(Trifluoromethyl)pyrazole is used as a key component in copper-catalyzed pyrazole N-arylation, a reaction that involves the formation of new carbon-carbon or carbon-heteroatom bonds. This application highlights its importance in the synthesis of various organic compounds.
Used in the Synthesis of Sodium Hydrodotris(1H-3-trifluoromethylpyrazol-1-yl)borate:
3-(Trifluoromethyl)pyrazole is used as a starting material for the synthesis of sodium hydridotris(1H-3-trifluoromethylpyrazol-1-yl)borate. 3-(Trifluoromethyl)pyrazole is prepared by heating 3-(trifluoromethyl)pyrazole with sodium borohydride, and it finds applications in various chemical reactions and processes.
Check Digit Verification of cas no
The CAS Registry Mumber 20154-03-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,1,5 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 20154-03:
(7*2)+(6*0)+(5*1)+(4*5)+(3*4)+(2*0)+(1*3)=54
54 % 10 = 4
So 20154-03-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H4ClF6N/c9-6-4(8(13,14)15)1-3(2-5(6)16)7(10,11)12/h1-2H,16H2
20154-03-4Relevant articles and documents
Gas-phase reactions of benzene and derivatives triggered by hydrazine/ozone; hydroxylation vs. degradation
Sol, Veronica M.,Mulder, Peter,Louw, Robert
, p. 577 - 582 (2007/10/02)
The reactions of benzene derivatives C6H5X (X = H, Cl, CH3 and CF3) with hydrazine and ozone in the dark (a source of OH radicals) have been studied in a flow reactor at ambient temperature. (Substituted) phenols were formed, but these were relatively unimportant compared to N-heterocyclic compounds (condensation products of cis-butenedial and analogues with hydrazine) and other (degradation) products.Benzene and (trifluoromethyl)benzene follow a similar path as toluene, also with oxidative ring opening as major reactions.
