202002-66-2

Basic information

• Product Name: 2-(piperidin-4-yl)acetonitrile
• Synonyms: 2-(piperidin-4-yl)acetonitrile;4-Piperidineacetonitrile;Piperidin-4-ylacetonitrile TFA
• CAS NO: 202002-66-2
• Molecular Formula: C₇H₁₂N₂
• Molecular Weight: 124.18358
• Mol File: 202002-66-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 247.487 °C at 760 mmHg
• Flash Point: 103.477 °C
• Appearance: /
• Density: 0.931 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.17±0.10(Predicted)
• CAS DataBase Reference: 2-(piperidin-4-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(piperidin-4-yl)acetonitrile(202002-66-2)
• EPA Substance Registry System: 2-(piperidin-4-yl)acetonitrile(202002-66-2)

Safety Data

• Hazardous Substances Data: 202002-66-2(Hazardous Substances Data)

Usage

General Description

2-(Piperidin-4-yl)acetonitrile is a chemical compound with the molecular formula C8H12N2. It is a white solid that is soluble in organic solvents such as ethanol and acetone. 2-(Piperidin-4-yl)acetonitrile is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It can also be used as a building block in the production of other organic compounds. In addition, 2-(Piperidin-4-yl)acetonitrile has been studied for its potential as a reagent in chemical reactions and as a precursor for the development of new materials. However, it should be handled with care as it can be harmful if ingested or inhaled, and may cause skin and eye irritation.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 197569-11-2 4-(cyanomethylidene)piperidine-1-carboxylic acid tert-butyl ester 
• 184044-10-8 4-piperidineacetamide 
• 51052-78-9 4-piperidinylacetic acid 
• 383865-57-4 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine 
• 256411-39-9 tert-butyl 4-(cyanomethyl)piperidine-1-carboxylate 

Downstream Products

• 86945-25-7 4-(2-aminoethyl)-1-(phenylmethyl)piperidine 
• 153567-02-3 4-(2-aminoethyl)-1-(cyclohexylmethyl)piperidine 

Relevant articles and documents

Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors

A series of tryptophan-based selective nanomolar butyrylcholinesterase (BChE) inhibitors was designed and synthesized. Compounds were optimized in terms of potency, selectivity, and synthetic accessibility. The crystal structure of the inhibitor 18 in complex with BChE revealed the molecular basis for its low nanomolar inhibition (IC50 = 2.8 nM). The favourable in vitro results enabled a first-in-animal in vivo efficacy and safety trial, which demonstrated a positive impact on fear-motivated and spatial long-term memory retrieval without any concomitant adverse motor effects. Altogether, this research culminated in a handful of new lead compounds with promising potential for symptomatic treatment of patients with Alzheimer's disease.

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine: where A is C(H)= or -N= and R1-7 are as defined herein.