20201-03-0 Usage
General Description
2-Chloro-4-nitro-benzenesulfonyl chloride, also known as NBS-Cl, is a chemical compound with the formula C6H3ClN2O4S. It is a white to pale yellow crystalline solid that is soluble in organic solvents such as dichloromethane and chloroform. It is commonly used as a reagent in organic synthesis, especially in the preparation of sulfonyl chlorides, sulfonamides, sulfonate esters, and other sulfur-containing compounds. NBS-Cl is known for its strong electrophilic and leaving group abilities, making it useful in reactions involving nucleophilic substitution and electrophilic aromatic substitution. It is also used in the production of pharmaceuticals, dyes, and agrochemicals. However, it is important to handle NBS-Cl with caution as it is a hazardous substance that can cause skin and eye irritation, as well as respiratory and digestive complications if inhaled or ingested.
Check Digit Verification of cas no
The CAS Registry Mumber 20201-03-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,2,0 and 1 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 20201-03:
(7*2)+(6*0)+(5*2)+(4*0)+(3*1)+(2*0)+(1*3)=30
30 % 10 = 0
So 20201-03-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H3Cl2NO4S/c7-5-3-4(9(10)11)1-2-6(5)14(8,12)13/h1-3H
20201-03-0Relevant articles and documents
Metal Free Bi(hetero)aryl Synthesis: A Benzyne Truce-Smiles Rearrangement
Holden, Catherine M.,Sohel, Shariar M. A.,Greaney, Michael F.
supporting information, p. 2450 - 2453 (2016/02/18)
A new benzyne transformation is described that affords versatile biaryl structures without recourse to transition-metal catalysis or stoichiometric amounts of organometallic building blocks. Aryl sulfonamides add to benzyne upon fluoride activation, and then undergo an aryl Truce-Smiles rearrangement to afford biaryls with sulfur dioxide extrusion. The reaction proceeds under simple reaction conditions and has excellent scope for the synthesis of sterically hindered atropisomeric biaryl amines. All smiles: Metal-free biaryl synthesis is achieved by adding benzyne to arylsulfonamides. A Smiles rearrangement enables C-C bond formation, thus accessing a variety of functionalized biaryls under mild reaction conditions.
