202822-68-2Relevant articles and documents
A BMS - 191011 synthetic method
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, (2017/08/23)
The invention relates to a synthetic method for a compound BMS-191011. The method comprises the following steps: taking 4-trifluoromethyl benzoyl hydrazine as a raw material and performing steps of oxidative carbonylation, methyl protection, halogenation, amination, deprotection and the like to prepare BMS-191011. The synthetic method adopts a CO balloon for replacing phosgene, so that the reaction toxicity is reduced and the reaction operability is improved. The method has the characteristics of simple and easily available raw materials, mild reaction conditions and simple operation process.
PHOSPHATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE
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, (2008/06/13)
The present invention provides novel phosphate derivatives having the general formula wherein A, R1 and R2 are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are resp
Derivatives of 1,3,4-oxadiazolone
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, (2008/06/13)
The present invention provides novel oxadiazolone derivatives having the general formula wherein A, B, D and R are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are