202865-65-4

Basic information

• Product Name: 5-BROMO-2-FLUOROBENZALDOXIME
• Synonyms: 5-BROMO-2-FLUOROBENZALDOXIME;5-BROMO-2-FLUOROBENZALDOXINE
• CAS NO: 202865-65-4
• Molecular Formula: C₇H₅BrFNO
• Molecular Weight: 218.02
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 202865-65-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 262.794°C at 760 mmHg
• Flash Point: 112.734°C
• Appearance: /
• Density: 1.626g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.564
• PKA: 10.23±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-2-FLUOROBENZALDOXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-FLUOROBENZALDOXIME(202865-65-4)
• EPA Substance Registry System: 5-BROMO-2-FLUOROBENZALDOXIME(202865-65-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 202865-65-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H5BrFNO/c8-6-1-2-7(9)5(3-6)4-10-11/h1-4,11H/b10-4+

Upstream product

• 93777-26-5 5-bromo-2-fluorobenzaldehyde 

Downstream Products

• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 1404480-13-2 C₈H₈BrFN₂O 
• 1404480-11-0 C₁₀H₁₀BrFN₂O 
• 1404480-10-9 (E,Z)-5-bromo-2-fluoro-N-hydroxybenzimidoyl chloride 

Relevant articles and documents

Discovery of Natural Product-Based Fungicides (II): Semisynthesis and Biological Activity of Sarisan Attached 3-Phenylisoxazolines as Antifungal Agents

Many phytopathogenic fungi cause severe damage to crop yields. In continuation of our research aimed at the discovery and development of natural products-based fungicides, a series of thirty-one sarisan attached 3-phenylisoxazolines were synthesized and evaluated for their antifungal activities against five phytopathogenic fungi (B. cinerea, C. lagenarium, A. solani, F. solani, and F. graminearum). Among all title sarisan derivatives, compounds IV2, IV14 and IV23 showed potent antifungal activity against some phytopathogenic fungi. In particular, compound IV2 exhibited a broad-spectrum and more potent antifungal activity against A. solani, F. solani, and F. graminearum than the commercial fungicide Hymexazol. In addition, compounds IV2, IV14 and IV23 also displayed relative low toxicity on normal NRK-52E cells. This work will give some insights into the development of sarisan derivatives as new fungicide candidates in plant protection.

Enhanced treatment regimens using mTor inhibitors

The present invention provides for methods and pharmaceutical compositions comprising inhibitors of mTorC1 and/or mTorC2. In some aspects, the invention provides for treatment regimens resulting in enhanced treatment efficacy and better tolerability.

COMBINATION PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present invention provides for methods and pharmaceutical compositions for treating proliferative disorders. In one aspect, the method comprises administration of two cell-cycle suppressors having a synergistic effect. In another aspect, two cell-cycle suppressors having a synergistic effect are provided in a pharmaceutical composition.