2030410-25-2

Basic information

• Product Name: glasdegib dimaleate
• CAS NO: 2030410-25-2
• Molecular Weight: 606.592
• Mol File: 2030410-25-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: glasdegib dimaleate(CAS DataBase Reference)
• NIST Chemistry Reference: glasdegib dimaleate(2030410-25-2)
• EPA Substance Registry System: glasdegib dimaleate(2030410-25-2)

Safety Data

• Hazardous Substances Data: 2030410-25-2(Hazardous Substances Data)

Upstream product

• 1095173-27-5 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea 
• 110-16-7 maleic acid 
• 873-74-5 4-Aminobenzonitrile 

Relevant articles and documents

DIMALEATE FORM OF 1-((2R,4R)-2-(1H-BENZO[D]IMIDAZOL-2-YL)-1-METHYLPIPERIDIN-4-YL)-3-(4-CYANOPHENYL)UREA

The present invention relates to a dimaleate form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)- 1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (INN: glasdegib) and a process of producing the same. Furthermore, the invention relates to a pharmaceutical composition comprising the dimaleate form of glasdegib and at least one pharmaceutically acceptable excipient. The pharmaceutical composition of the present invention can be used as a medicament, in particular for the treatment and/or prevention of cancers such as acute myeloid leukemia.

CRYSTALLINE FORMS OF 1-((2R,4R)-2-(1H-BENZO[D]IMIDAZOL-2-YL)-1-METHYLPIPERIDIN-4-YL)-3-(4-CYANOPHENYL)UREA MALEATE

This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol- 2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.