203056-16-0Relevant articles and documents
A practical one-pot synthesis of weinreb-like amides of (S)- and (R)-N-BOC-pipecolic acids from (±)-piperidine-2-carboxylic acid
Moldvai, Istvan,Doernyei, Gabor,Temesvari-Major, Eszter,Szantay, Csaba
, p. 503 - 508 (2007)
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Asymmetric synthesis and pharmacology of methylphenidate and its para- substituted derivatives
Thai, Dung L.,Sapko, Michael T.,Reiter, Clara T.,Bierer, Donald E.,Perel, James M.
, p. 591 - 601 (2007/10/03)
We report the first asymmetric synthesis of the individual enantiomers of methylphenidate (1). From d-pipecolic acid, the (2R,2'R) and (2S,2'R) enantiomers of 1 were obtained in >99% optical purity while the (2S,2'S) and (2R,2'S) enantiomers of 1 were der