91-02-1 Usage
Description
2-Benzoylpyridine is a colorless to slightly yellow crystalline compound that serves as a versatile reagent and precursor in various chemical applications.
Uses
Used in Organic Synthesis:
2-Benzoylpyridine is used as a reagent in organic synthesis, facilitating the formation of complex organic molecules and contributing to the development of new chemical compounds.
Used in Polymers Industry:
In the polymers industry, 2-Benzoylpyridine is used as a reagent to assist crosslinking in acrylic coating compounds. This enhances the properties of the coatings, such as durability, adhesion, and resistance to environmental factors.
Used in Pharmaceutical Research:
2-Benzoylpyridine is a precursor for thioemicarbazone compounds, which exhibit high cytotoxic activity against human leukemia cell lines. This makes it a valuable component in the development of potential anti-cancer drugs.
Additionally, 2-Benzoylpyridine possesses some anti-inflammatory qualities, which can be beneficial in the research and development of medications for inflammatory conditions.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 24, p. 1061, 1987 DOI: 10.1002/jhet.5570240429Tetrahedron Letters, 25, p. 1715, 1984 DOI: 10.1016/S0040-4039(01)81152-7
Purification Methods
Dissolve 2-benzoylpyridine in Et2O, shake it with aqueous NaHCO3, H2O, dry it over MgSO4 and evaporate. The residue solidifies on cooling. The solid can be recrystallised from pet ether. Its hydrochloride crystallises from Me2CO, m 126-127o, and the 2,4-dinitrophenylhydrazone has m 193-195o. It distils at high vacuum. [Kinkerton & Thames J Organomet Chem 24 623 1970, Beilstein 21/8 V 566.]
Check Digit Verification of cas no
The CAS Registry Mumber 91-02-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 1 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 91-02:
(4*9)+(3*1)+(2*0)+(1*2)=41
41 % 10 = 1
So 91-02-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H9NO/c14-12(10-6-2-1-3-7-10)11-8-4-5-9-13-11/h1-9H
91-02-1Relevant articles and documents
Ruthenium-catalyzed meta -C-H bond alkylation of aryl 2-pyridyl ketones
Li, Gang,Jia, Chunqi,Cai, Xiaofeng,Zhong, Lei,Zou, Lei,Cui, Xiuling
, p. 293 - 296 (2019)
The first example of meta-selective CAr-H bond functionalization of aryl 2-pyridyl ketones has been developed using [Ru(p-cymene)Cl2]2 as the catalyst and alkyl bromide as the coupling reagent. This development provides an efficient strategy for modifying the meta-position of aryl 2-pyridyl ketone skeletons, which are found in various functional molecules.
Poly(ethylene glycol) dimethyl ether mediated oxidative scission of aromatic olefins to carbonyl compounds by molecular oxygen
Yu, Tao,Guo, Mingqing,Wen, Simiaomiao,Zhao, Rongrong,Wang, Jinlong,Sun, Yanli,Liu, Qixing,Zhou, Haifeng
, p. 13848 - 13852 (2021/04/22)
A simple, and practical oxidative scission of aromatic olefins to carbonyl compounds using O2as the sole oxidant with poly(ethylene glycol) dimethyl ether as a benign solvent has been developed. A wide range of monosubstituted,gem-disubstituted, 1,2-disubstituted, trisubstituted and tetrasubstituted aromatic olefins was successfully converted into the corresponding aldehydes and ketones in excellent yields even with gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.
Photo-induced oxidative cleavage of C-C double bonds for the synthesis of biaryl methanoneviaCeCl3catalysis
Xie, Pan,Xue, Cheng,Du, Dongdong,Shi, SanShan
supporting information, p. 6781 - 6785 (2021/08/20)
A Ce-catalyzed strategy is developed to produce biaryl methanonesviaphotooxidative cleavage of C-C double bonds at room temperature. This reaction is performed under air and demonstrates high activity as well as functional group tolerance. A synergistic Ce/ROH catalytic mechanism is also proposed based on the experimental observations. This protocol should be the first successful Ce-catalyzed photooxidation reaction of olefins with air as the oxidant, which would provide inspiration for the development of novel Ce-catalyzed photochemical synthesis processes.
