31796-72-2

Basic information

• Product Name: (S)-(+)-α-phenyl-2-pyridylmethanol
• Synonyms: (S)-(+)-α-phenyl-2-pyridylmethanol
• CAS NO: 31796-72-2
• Molecular Weight: 185.225
• Mol File: 31796-72-2.mol
• Article Data: 133

Chemical Properties

• CAS DataBase Reference: (S)-(+)-α-phenyl-2-pyridylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-α-phenyl-2-pyridylmethanol(31796-72-2)
• EPA Substance Registry System: (S)-(+)-α-phenyl-2-pyridylmethanol(31796-72-2)

Safety Data

• Hazardous Substances Data: 31796-72-2(Hazardous Substances Data)

Upstream product

• 17624-36-1 2-pyridyllithium 
• 100-52-7 benzaldehyde 
• 504-29-0 2-aminopyridine 
• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 626-05-1 2,6-Dibromopyridine 
• 109-04-6 2-bromo-pyridine 
• 109-09-1 2-chloropyridine 
• 40864-08-2 2-benzyloxypyridine 
• 234111-09-2 6-bromo-α-phenyl-2-pyridinemethanol 
• 600700-48-9 (3S)-2-(2-methoxyethyl)-3,5-dimethyl-7,8-dimethoxy-1-oxo-1,2,3,4,5,10-hexahydrobenzo[b]-1,6-naphthyridine 
• 600700-50-3 (3S)-2-(2-hydroxyethyl)-3,5-dimethyl-7,8-dimethoxy-1-oxo-1,2,3,4,5,10-hexahydrobenzo[b]-1,6-naphthyridine 
• 600700-49-0 (3S)-2-(3-hydroxypropyl)-3,5-dimethyl-7,8-dimethoxy-1-oxo-1,2,3,4,5,10-hexahydrobenzo[b]-1,6-naphthyridine 
• 7677-24-9 trimethylsilyl cyanide 
• 74-86-2 acetylene 

Downstream Products

• 107060-28-6 {Ni(OH)2(C₁₂H₁₁NO)3} 
• 106955-11-7 {Ni(OH)2(C₁₂H₁₁NO)2} 
• 106197-23-3 {Cu(OCH(C₅H₄N)C₆H₅)2} 
• 5583-33-5 (R)-(-)-α-phenyl-2-pyridylmethanol 
• 5583-33-5 (S)-(+)-α-phenyl-2-pyridylmethanol 
• 33583-12-9 10-phenylpyrido[1,2-a]indole 
• 19490-90-5 diphenyl(2-pyridyl)methanol 
• 3678-70-4 Diphenyl-2-pyridylmethan 
• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 1438252-68-6 1-methyl-3-(phenyl(pyridin-2-yl)methyl)-1H-benzo[d]imidazol-3-ium chloride 
• 1234804-57-9 1‐methyl‐3‐[phenyl(pyridin‐2‐yl)methyl]‐1H‐imidazolium chloride 
• 1438252-69-7 1‐phenyl‐3‐[phenyl(pyridin‐2‐yl)methyl]‐1H‐imidazolium chloride 

Relevant articles and documents

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Amino alcohols using the optically active amino alcohol derivative bi- Nord complex boron - -

Disclosed are an amino alcohol-boron-binol complex as an intermediate, including Complex 3-1-1 shown below, and a method for preparing an optically active amino alcohol by using the same, wherein a racemic amino alcohol is resolved in an enationselective manner using a boron compound and a (R)- or (S)-binol, whereby an amino alcohol derivative with high optical purity can be prepared at high yield.

Electronic Effect-Guided Rational Design of Candida antarctica Lipase B for Kinetic Resolution Towards Diarylmethanols

Herein, we developed an electronic effect-guided rational design strategy to enhance the enantioselectivity of Candida antarctica lipase B (CALB) mutants towards bulky pyridyl(phenyl)methanols. Compared to W104A mutant previously reported with reversed S-stereoselectivity toward sec-alcohols, three mutants (W104C, W104S and W104T) displayed significant improvement of S-enantioselectivity in the kinetic resolution (KR) of various phenyl pyridyl methyl acetates due to the increased electronic effects between pyridyl and polar residues. The electronic effects were also observed when mutating other residues surrounding the stereospecificity pocket of CALB, such as T42A, S47A, A281S or A281C, and can be used to manipulate the stereoselectivity. A series of bulky pyridyl(phenyl) methanols, including S-(4-chlorophenyl)(pyridin-2-yl) methanol (S-CPMA), the intermediate of bepotastine, were obtained in good yields and ee values. (Figure presented.).

Palladium-Catalyzed Direct Arylation of 2-Pyridylmethyl Silanes with Aryl Bromides

The first palladium-catalyzed direct arylation of 2-pyridylmethyl silanes with aryl bromides to generate a diverse array of aryl(2-pyridyl)-methyl silane derivatives has been developed. This protocol facilitates access to various kinds of heterocycle-containing silanes in good to excellent yields (40 examples, 66-97% yield) with good functional group tolerance. The scalability of this transformation is demonstrated.