20315-68-8Relevant articles and documents
Catalytic Enantioselective Synthesis of Spirooxindoles by Oxidative Rearrangement of Indoles
Qian, Chenxiao,Li, Pengfei,Sun, Jianwei
supporting information, p. 5871 - 5875 (2021/02/06)
Oxidative rearrangement of indoles to access oxindoles has been used as a key step in complex molecule synthesis. We report a catalytic enantioselective variant of this transformation by chiral phosphoric acid catalysis, providing rapid access to a range of enantioenriched spirooxindoles. The high enantioselectivity is controlled by dynamic kinetic resolution.
Aromatic heterocyclic derivative and application thereof in medicine
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Paragraph 0517; 0519-0520, (2020/02/08)
The invention provides aromatic heterocyclic derivatives or stereoisomers, tautomers, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, which are used for treating Alzheimer's disease. The invention also discloses pharmaceutical compositions containing the compounds and a method for treating Alzheimer's disease by using the compounds or the pharmaceutical compositions provided by the invention.
Aryl substituted aminotetrahydropyran compound and use thereof
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Paragraph 0355; 0359; 0360, (2019/07/04)
The invention relates to an aryl substituted aminotetrahydropyran compound and use thereof, and further relates to a pharmaceutical composition comprising the compound. The compound or pharmaceuticalcomposition provided by the invention can be used as a dipeptidyl peptidase-IV (DPP-IV) inhibitor.