58982-28-8Relevant articles and documents
6-Hydroxy- and 6-methoxy-β-carbolines as acetyl- and butyrylcholinesterase inhibitors
Schott, Yvonne,Decker, Michael,Rommelspacher, Hans,Lehmann, Jochen
, p. 5840 - 5843 (2007/10/03)
In the course of studies directed toward the discovery of novel acetyl- and butyrylcholinesterase (AChE and BChE) inhibitors for the treatment of Alzheimer's disease, we focused on β-carbolines (BCs). 6-Oxygenated β-carboline and β-carbolinium derivatives based on the serotonin template were synthesized and tested in vitro for their ability to inhibit AChE and BChE, respectively. Particularly the carbolinium salts, which can be formed by intracerebral methylation out of the tertiary-BC prodrugs, show inhibitory activity levels reaching those of galantamine, physostigmine, and rivastigmine.
Carbolines. Part VII. Anisidines, convenient tools to synthesize hydroxy-β-carbolines
Rocca,Marsais,Godard,Queguiner,Adams,Alo
, p. 1171 - 1175 (2007/10/02)
The paper describes a convenient synthesis of hydroxy-β-carbolines from commercial anisidines based on key steps such as metalation, cross-coupling and cyclization. The first total synthesis of a major cytotoxic constituent of a marine bryozoan is also re
A convenient synthesis of 6-hydroxyharman
Rocca, Patrick,Marsais, Francis,Godard, Alain,Queguiner, Guy
, p. 2003 - 2004 (2007/10/02)
A three-step synthesis of 6-hydroxyharman and 6-hydroxynorharman from benzene and pyridine blocks is described. The preparation of the two α-substituted β-carbolines is based on a new synthetic methodology which involves reactions such as Directed Ortho M
