203504-59-0

Basic information

• Product Name: 4-Methyl-benzenesulfinic acid [(R)-(3,5-bis-benzyloxy-4-methoxy-phenyl)-cyano-methyl]-amide
• Synonyms: 4-Methyl-benzenesulfinic acid [(R)-(3,5-bis-benzyloxy-4-methoxy-phenyl)-cyano-methyl]-amide
• CAS NO: 203504-59-0
• Molecular Weight: 512.629
• Mol File: 203504-59-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Methyl-benzenesulfinic acid [(R)-(3,5-bis-benzyloxy-4-methoxy-phenyl)-cyano-methyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-benzenesulfinic acid [(R)-(3,5-bis-benzyloxy-4-methoxy-phenyl)-cyano-methyl]-amide(203504-59-0)
• EPA Substance Registry System: 4-Methyl-benzenesulfinic acid [(R)-(3,5-bis-benzyloxy-4-methoxy-phenyl)-cyano-methyl]-amide(203504-59-0)

Safety Data

• Hazardous Substances Data: 203504-59-0(Hazardous Substances Data)

Upstream product

• 91796-57-5 4-Methyl-benzenesulfinic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 
• 13326-69-7 methyl 3,5-bis(benzyloxy)-4-methoxybenzoate 
• 13326-72-2 3,5-bis(benzyloxy)-4-methoxybenzaldehyde 
• 203504-55-6 4-Methyl-benzenesulfinic acid 1-(3,5-bis-benzyloxy-4-methoxy-phenyl)-meth-(Z)-ylideneamide 
• 5804-85-3 diethylaluminium cyanide 

Downstream Products

• 174146-47-5 (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dihydroxy-4-methoxyphenyl)acetic acid 
• 203504-61-4 (R)-(-)-(3,5-dihydroxy-4-methoxyphenyl)glycine 

Relevant articles and documents

Sulfinimine-mediated asymmetric synthesis of (R)-(4-methoxy-3,5-dihydroxyphenyl)glycine: The central amino acid of vancomycin and related agents

The sulfinimine asymmetric Strecker synthesis, the addition of ethyl aluminum cyano alkoxide, 'EtAl(OR)CN' to sulfinimine 10, has been applied to a concise highly efficient four-step enantioselective synthesis of (R)-(4-methoxy-3,5-dihydroxyphenyl)glycine (3) and its derivatives in >97% ee. These epimerization-sensitive arylglycines are precursors of the key central amino acid of vancomycin and related glycopeptide antibiotics.