20357-22-6

Basic information

• Product Name: 4-Methyl-2-nitrobenzaldehyde
• Synonyms: 4-METHYL-2-NITROBENZALDEHYDE;2-Nitro-4-methylbenzaldehyde
• CAS NO: 20357-22-6
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Mol File: 20357-22-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 309.4 °C at 760 mmHg
• Flash Point: 154.9 °C
• Appearance: /
• Density: 1.278 g/cm³
• Vapor Pressure: 0.000642mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Methyl-2-nitrobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-2-nitrobenzaldehyde(20357-22-6)
• EPA Substance Registry System: 4-Methyl-2-nitrobenzaldehyde(20357-22-6)

Safety Data

• Hazardous Substances Data: 20357-22-6(Hazardous Substances Data)

Usage

General Description

4-Methyl-2-nitrobenzaldehyde is an organic compound with the chemical formula C8H7NO3. It is a yellow crystalline solid that is commonly used as a building block in organic synthesis. This chemical is primarily utilized in the production of pharmaceuticals, dyes, and perfumes. It is also a key intermediate in the manufacturing of various agrochemicals and other specialty chemicals. Additionally, 4-Methyl-2-nitrobenzaldehyde has been studied for its potential anti-cancer and anti-inflammatory properties, making it an important compound in the field of medicinal chemistry. However, it is important to handle this compound with care as it is toxic and should be used in a well-ventilated area.

InChI:InChI=1/C8H7NO3/c1-6-2-3-7(5-10)8(4-6)9(11)12/h2-5H,1H3

Upstream product

• 50-00-0 formaldehyd 
• 89-62-3 4-methyl-2-nitroaniline 
• 17343-70-3 1,1-dichloro-2-(4-methylphenyl)cyclopropane 
• 20587-29-5 methyl 4-methyl-2-nitrobenzoate 
• 27329-27-7 4-methyl-2-nitrobenzoic acid 
• 1455471-51-8 2,2'-(2-nitro-1,4-phenylene)diacetic acid 
• 7325-46-4 1,4-phenylenediacetic acid 
• 75-17-2 formaldoxime 
• 22996-24-3 (4-methyl 2-nitro-phenyl)-methanol 

Downstream Products

• 143883-00-5 13-(4-Methyl-2-nitro-phenyl)-12,13-dihydro-7,12,13a-triaza-benzo[hi]chrysene 
• 105910-05-2 3-(4-methyl-2-nitrophenyl)acrylic acid ethyl ester 
• 1031928-45-6 7-methyl-3-phenylquinolin-2(1H)-one 
• 106269-39-0 9-oxo-9H-xanthene-3-carboxylic acid 
• 19814-98-3 3-methyl-9H-xanthen-9-one 
• 85355-46-0 4-methyl-2-nitrophenylacetaldehyde 
• 29640-91-3 methyl 2-(4-methyl-2-nitrophenyl)acetate 
• 29640-90-2 (4-methyl-2-nitro-phenyl)-acetic acid 
• 916845-88-0 methyl 2-(4-methyl-2-nitrophenyl)propanoate 
• 1313592-04-9 sodium 2-{2-nitro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoate 
• 1313592-01-6 methyl 1-[4-(1-methoxy-1-oxopropan-2-yl)-3-nitrobenzyl]-2-oxocyclopentanecarboxylate 
• 170990-43-9 ethyl 4-hydroxy-4(4-methyl-2-nitrophenyl)-2-butynoate 
• 103204-27-9 2-amino-4-methyl-trans-cinnamic acid 
• 109466-90-2 11-methyl-20(RS)-camptothecin 

Relevant articles and documents

Compound with dual inhibitory activity TDO, IDOO1 and application of compound for treating neurodegenerative disease (by machine translation)

The present invention provides a compound of formula I, or a pharmaceutically acceptable salt thereof, or a solvate thereof, which can selectively inhibit TDO, IDOO1, which has a significant inhibitory effect on TDO and/or IDOO1. In addition, the prepared compound has a remarkable anti-tumor effect, has a certain treatment effect on's disease and's disease, and has a good application prospect in the field of medicine preparation. (by machine translation)

Novel access to carbonyl and acetylated compounds: The role of the tetra-: N -butylammonium bromide/sodium nitrite catalyst

A novel aerobic oxidation of alcohols without the use of any oxidants was developed. An equimolar catalytic mixture of tetra-n-butylammonium bromide and sodium nitrite catalyzes the aerobic selective oxidation of benzylic alcohols under oxidant-free, base-free and metal-free conditions. The mild reaction conditions allow oxidation of a wide range of benzylic alcohols, chemo-selectively to their carbonyl compounds (68-93% isolated yields). More importantly, high selectivity among different kinds of alcohols (aromatic vs. aliphatic alcohols, primary vs. secondary alcohols as well as alcohols having neutral rings vs. electron-deficient rings) is available by this approach. The method surprisingly switched over to be an efficient acetylation approach in the case of aliphatic alcohols without the use of any transition metal, phosphorous or other toxic reagents or any need for using toxic acyl halides, sulfonyl halides, anhydrides, etc. by the use of only acetic acid as a reagent.

COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.