20366-59-0 Usage
General Description
1-Bromo-5-methylnaphthalene is a chemical compound with the molecular formula C11H9Br. It is a derivative of naphthalene, which is a polycyclic aromatic hydrocarbon. 1-Bromo-5-methylnaphthalene is widely used in organic synthesis as a reactant for the preparation of various organic compounds. It is also used as a building block in the production of pharmaceuticals and agrochemicals. 1-Bromo-5-methylnaphthalene is primarily utilized as a reagent in the production of intermediate and end products in the pharmaceutical and chemical industries. Additionally, it is used in research and development as a reference standard in analytical chemistry and quality control. This chemical is flammable and should be handled with caution in a well-ventilated area and with proper personal protective equipment.
Check Digit Verification of cas no
The CAS Registry Mumber 20366-59-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,3,6 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 20366-59:
(7*2)+(6*0)+(5*3)+(4*6)+(3*6)+(2*5)+(1*9)=90
90 % 10 = 0
So 20366-59-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H9Br/c1-8-4-2-6-10-9(8)5-3-7-11(10)12/h2-7H,1H3
20366-59-0Relevant articles and documents
Syntheses of 1-bromo-8-methylnaphthalene and 1-bromo-5-methylnaphthalene
Onyango, Evans O.,Kelley, Anne R.,Qian, David C.,Gribble, Gordon W.
, p. 5970 - 5972 (2015)
The Diels-Alder reaction between 2-methylfuran and 3-bromobenzyne (3), which was generated under mild conditions from 1,3-dibromobenzene and lithium diisopropylamide (LDA), gives a mixture of regioisomeric 1,4-dihydro-1,4-epoxynaphthalenes 4 and 5. A subsequent two-step deoxygenation affords the corresponding 1-bromo-8-methylnaphthalene (1) and 1-bromo-5-methylnaphthalene (2) in high yields.
KRAS G12C INHIBITORS
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Paragraph 0365-0366, (2020/03/23)
The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
Diastereoselective synthesis of β-aryl-C-nucleosides from 1,2-anhydrosugars
Singh, Ishwar,Seitz, Oliver
, p. 4319 - 4322 (2007/10/03)
(Chemical Equation Presented) The cis opening of glycal epoxides with arylaluminum reagents provides strict stereocontrol in C-glycosylation. β-Aryl-C-2-deoxynucleosides are obtained from known glycals by an epoxidation-glycosylation-deoxygenation sequenc
