68449-30-9

Basic information

• Product Name: 5-Bromo-1-tetralone
• Synonyms: 5-BROMO-1-TETRALONE;5-BROMOTETRALONE;5-BROMO-3,4-DIHYDRO-1(2H)-NAPHTHALENONE;5-BROMO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE;5-Bromo-3,4-dihydro-2H-naphthalen-1-one;5-BROMO-A-TETRALONE;5-broMo-1,2,3,4-tetrahydronaphthalen-1-one;5-Bromo-1-tetralone, 5-Bromo-1-oxo-1,2,3,4-tetrahydronaphthalene
• CAS NO: 68449-30-9
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225.08
• Product Categories: Benzocycles;CHIRAL CHEMICALS
• Mol File: 68449-30-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 47-48 °C(Solv: methanol (67-56-1))
• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 111.7 °C
• Appearance: /
• Density: 1.511 g/cm³
• Vapor Pressure: 0.000261mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-Bromo-1-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-1-tetralone(68449-30-9)
• EPA Substance Registry System: 5-Bromo-1-tetralone(68449-30-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 68449-30-9(Hazardous Substances Data)

Usage

Description

5-Bromotetralone is a synthetic intermediate useful for pharmaceutical synthesis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 4226, 1984 DOI: 10.1021/jo00196a024

InChI:InChI=1/C10H9BrO/c11-9-5-1-4-8-7(9)3-2-6-10(8)12/h1,4-5H,2-3,6H2

Upstream product

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Downstream Products

• 42775-75-7 5-ethyltetralin 
• 66325-42-6 5-n-butyltetralin 
• 909248-38-0 5-bromo-1-tetralone p-toluenesulfonhydrazone 
• 138764-20-2 5-oxo-5,6,7,8-tetrahydronaphthalene-1-carbonitrile 
• 62784-49-0 5-bromo-1,2-naphthaquinone 
• 346690-13-9 4-bromo-benzo[a]phenazine-11-carboxylic acid 
• 97903-08-7 ethyl 5-<2-(tosyloxy)ethyl>-5,6,7,8-tetrahydronaphthalene-1-carboxylate 
• 20366-59-0 1-bromo-5-methylnaphthalene 
• 911836-29-8 1'-deoxy-1'-β-(5-phenylnaphth-1-yl)-3',5'-bis-O-tert-butyldimethylsilyl-2'-O-thionocarbonylimidazolyl-arabinose 
• 911836-25-4 1'-deoxy-1'-β-(5-phenylnaphth-1-yl)-3',5'-bis-O-tert-butyldimethylsilyl-arabinose 
• 911836-33-4 1',2'-dideoxy-1'-β-(5-phenylnaphth-1-yl)-3',5'-bis-O-tert-butyldimethylsilyl-ribose 
• 911836-38-9 1-bromo-5-phenylnaphthalene 
• 910330-27-7 5-phenyl-3,4-dihydronaphthalen-2(1H)-one 
• 910330-28-8 5-(m-trifluoromethylphenyl)-2-tetralone 

Relevant articles and documents

Synthesis of multisubstituted cycloalkenes through carbomagnesiation of strained cycloalkynes

An efficient synthetic method of seven- and six-membered cycloalkenes through the generation of strained cycloalkynes and following carbomagnesiation is described. Further bond formations of the resulting cycloalkenylmagnesium intermediates with a wide variety of electrophiles enabled us to prepare diverse cycloalkene derivatives including benzoxepine analogs having a fully substituted alkene structure.

Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease

A series of compounds bearing tetrahydronaphthalene, benzophenone, propiophenone, and related rigid molecular skeletons functionalized with thiosemicarbazone or unsaturated carbonyl moieties were prepared by chemical synthesis and evaluated for their ability to inhibit the enzyme cruzain. As potential treatment agents for Chagas' disease, three compounds from the group demonstrate potent inhibition of cruzain with IC50 values of 17, 24, and 80 nM, respectively.

5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa

Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa potency and equal or slightly better selectivity relative to factor Xa. Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa activity and equal or slightly better selectivity relative to factor Xa.