204642-98-8 Usage
Description
(S)-Verapamilamide, also known as (S)-Verapamil, is a pharmaceutical compound derived from the synthesis of Verapamil. It is a calcium channel blocker with vasodilatory properties, which makes it useful in the treatment of various cardiovascular conditions. The compound is characterized by its brown syrup appearance.
Uses
Used in Pharmaceutical Industry:
(S)-Verapamilamide is used as an active pharmaceutical ingredient for the treatment of cardiovascular diseases, such as hypertension, angina, and arrhythmias. It functions by blocking the movement of calcium ions into heart and blood vessel muscle cells, leading to relaxation and dilation of blood vessels, which in turn reduces blood pressure and improves blood flow.
Used in Research and Development:
(S)-Verapamilamide serves as a precursor in the synthesis of other related compounds with potential therapeutic applications. Its role in the development of novel drugs highlights its importance in the field of medicinal chemistry and drug discovery.
Used in Drug Delivery Systems:
Similar to Gallotannin, (S)-Verapamilamide can also be incorporated into drug delivery systems to enhance its bioavailability, targeting, and therapeutic efficacy. These systems may include nanoparticles, liposomes, or other advanced formulations designed to improve the compound's pharmacokinetic and pharmacodynamic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 204642-98-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,4,6,4 and 2 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 204642-98:
(8*2)+(7*0)+(6*4)+(5*6)+(4*4)+(3*2)+(2*9)+(1*8)=118
118 % 10 = 8
So 204642-98-8 is a valid CAS Registry Number.
InChI:InChI=1/C27H36N2O5/c1-19(2)27(18-28,21-9-11-23(32-5)25(17-21)34-7)14-12-26(30)29(3)15-13-20-8-10-22(31-4)24(16-20)33-6/h8-11,16-17,19H,12-15H2,1-7H3/t27-/m0/s1
204642-98-8Relevant articles and documents
A scaleable route to the pure enantiomers of verapamil
Bannister, Robin M.,Brookes, Michael H.,Evans, Graham R.,Katz, Ruth B.,Tyrrell, Nicholas D.
, p. 467 - 472 (2000)
A versatile route to single enantiomer verapamil from readily available raw materials is described. The key intermediate, 4-cyano-4-(3,4-dimethoxyphenyl)-5-methyl hexanoic acid (verapamilic acid), was resolved efficiently with α-methyl benzylamine. Stereochemical integrity at the quaternary carbon centre was preserved through subsequent steps to give either (R)-or (S)-verapamil in good overall yield. This sequence incorporated a selective borane-mediated reduction of a tertiary amide. Process scale-up to the pilot plant has been demonstrated successfully for the resolution step.
