20535-83-5

Basic information

• Product Name: 6-Methoxyguanine
• Synonyms: O6-METHYLGUANINE;O-METHYLGUANINE;2-amino-6-methoxy-purin;6-methoxy-1h-purin-2-amin;6-methoxy-1h-purine-2-amine;o(sup6)-methylguanine;6-Methoxyguanine;6-methoxy-1h-purin-2-amine
• CAS NO: 20535-83-5
• Molecular Formula: C₆H₇N₅O
• Molecular Weight: 165.16
• EINECS: 1312995-182-4
• Product Categories: Amines;Purine;Chemical Amines;Purines;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Fused Ring Systems;Intermediate in the synthesis of Tropine and respective derivatives
• Mol File: 20535-83-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 598.5 °C at 760 mmHg
• Flash Point: 315.8 °C
• Appearance: Off-white solid
• Density: 1.531 g/cm³
• Vapor Pressure: 0.00232mmHg at 25°C
• Refractive Index: 1.814
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Slightly, Heated), Water (Slightly, Heated)
• PKA: 9.74±0.10(Predicted)
• BRN: 645384
• CAS DataBase Reference: 6-Methoxyguanine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxyguanine(20535-83-5)
• EPA Substance Registry System: 6-Methoxyguanine(20535-83-5)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: UO7473000
• Hazardous Substances Data: 20535-83-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

Uses

Different sources of media describe the Uses of 20535-83-5 differently. You can refer to the following data:
1. Antitumor agent
2. These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Definition

ChEBI: A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

InChI:InChI=1/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2-3H,1H3,(H2,7,8,9,10)

Downstream Products

• 1234492-62-6 ((2S,4R)-4-acetoxy-5-(2-amino-6-methoxy-9H-purin-9-yl)-4-methyl-tetrahydrofuran-2-yl)methyl benzoate 
• 68-94-0 hypoxanthine 
• 7803-88-5 6-O-methylguanosine 
• 62962-42-9 N²,3-ethenoguanine 
• 964-21-6 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine 
• 67-56-1 methanol 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 1198-46-5 2-chloro-6-methoxypurine 
• 2958-98-7 3-methylguanine 
• 879-08-3 9-Ethylguanine 
• 119901-98-3 9-aminoguanine 
• 127770-65-4 3,7-diaminoguanine 
• 177162-17-3 2-amino-7-[2-deoxy-3,5-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl]-6-methoxy-7H-purine 

Relevant articles and documents

Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides

A method for treating two specific protozoal infections, Trichomonas vaginalis and Giardia lamblia, comprising the administration to a mammal in need thereof one of the following purine nucleosides: 2,6-diamino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine 2-amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine 2-amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-6-methoxy-9H-purine.