20561-09-5

Basic information

• Product Name: DIETHYL 1,2-CYCLOPROPANEDICARBOXYLATE
• Synonyms: DIETHYL 1,2-CYCLOPROPANEDICARBOXYLATE;RARECHEM AL BI 0655;diethyl cyclopropane-1,2-dicarboxylate;ethyl 1,2-cyclopropanedicarboxylate;1,2-Cyclopropanedicarboxylic acid diethyl ester;1,2-Bis(ethoxycarbonyl)cyclopropane;1,2-Cyclopropanedicarboxylicacid 1,2-Diethyl Ester;diethyl (cis,trans)-1,2-cyclopropanedicarboxylate
• CAS NO: 20561-09-5
• Molecular Formula: C₉H₁₄O₄
• Molecular Weight: 186.21
• EINECS: 243-878-2
• Mol File: 20561-09-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 70-75 °C (1 mmHg)
• Flash Point: 98 °C
• Appearance: /
• Density: 1.06
• Vapor Pressure: 0.0274mmHg at 25°C
• Refractive Index: 1.44-1.442
• Storage Temp.: 2-8°C
• CAS DataBase Reference: DIETHYL 1,2-CYCLOPROPANEDICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 1,2-CYCLOPROPANEDICARBOXYLATE(20561-09-5)
• EPA Substance Registry System: DIETHYL 1,2-CYCLOPROPANEDICARBOXYLATE(20561-09-5)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 20561-09-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H14O4/c1-3-12-8(10)6-5-7(6)9(11)13-4-2/h6-7H,3-5H2,1-2H3/t6-,7-/m0/s1

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 140-88-5 ethyl acrylate 
• 75-65-0 tert-butyl alcohol 
• 818-38-2 Diethyl glutarate 
• 7732-18-5 water 
• 623-73-4 diazoacetic acid ethyl ester 

Downstream Products

• 696-74-2 cis-1,2-cyclopropanedicarboxylic acid 
• 167113-73-7 D,L-Trans-2-Ethoxycarbonylcyclopropane-1-carboxylic acid 
• 710-43-0 cis-cyclopropane-1,2-dicarboxylic acid diethyl ester 
• 826-34-6 dimethyl cis-cyclopropane-1,2-dicarboxylate 
• 89180-99-4 (1R,2R)-Cyclopropane-1,2-dicarbonyl dichloride 
• 1489-58-3 trans-1,2-cyclopropanedicarboxylic acid 
• 5617-74-3 cis-1,2-cyclopropanedicarboxylic acid anhydride 
• 5617-74-3 3-oxabicyclo[3.1.0]hexane-2,4-dione 

Relevant articles and documents

Palladium(II) Acetate, an Efficient Catalyst for Cyclopropanation Reactions with Ethyl Diazoacetate

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Synthetic method of alicyclic diester

The invention discloses a synthetic method of alicyclic diester. The synthetic method comprises the following steps: enabling diacid comprising a multi-carbon lipid chain end group or diester containing a multi-carbon lipid chain end group to react with a first halogenation reagent, after the reaction is completed, adding a second halogenation reagent into a reaction product, after the reaction iscompleted, re-esterifying, and obtaining the di-ester of di-halogenation; adding the di-ester of the di-halogenation into an organic solvent, adding alkali to perform the reaction, after the reactionis completed, adding acid to perform the neutralization, and obtaining annular di-ester; and performing the reduction reaction for the annular di-ester, and obtaining the alicyclic diester. By adopting the synthetic method, a novel reaction path is developed, and the direct-chain end-group diacid or diester is used as a raw material to prepare the alicyclic diester by virtue of bromination reaction, ring-closing reaction and the reduction reaction. The initial raw material is low in cost, the process is simple, the reaction condition requirement is low, the safety is good, the product yield and purity are high, and the mass production is easy to realize. Moreover, the diester of a three-membered ring to an eighteen-membered ring can be prepared by utilizing the synthetic method of the invention.

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

The synthesis and structure-activity relationships of novel dipeptidyl peptidase IV inhibitors replacing the classical cyanopyrrolidine P1 group with other small nitrogen heterocycles are described. A unique potency enhancement was achieved with β-branched natural and unnatural amino acids, particularly adamantylglycines, linked to a (2S,3R)-2,3-methanopyrrolidine based scaffold.

Facile Synthesis of Polysubstituted Cyclopropanes in a Two-Phase Solid-Liquid System

The Michael addition of α-chloro esters to α,β-unsaturated systems was catalyzed by phase transfer catalyst, and the some polysubstituted cyclopropanes were facilly synthesized.