89180-99-4

Basic information

• Product Name: 1,2-Cyclopropanedicarbonyl chloride (6CI,7CI)
• Synonyms: 1,2-Cyclopropanedicarbonyl chloride (6CI,7CI)
• CAS NO: 89180-99-4
• Molecular Formula: C₅H₄Cl₂O₂
• Molecular Weight: 166.99006
• Product Categories: ACIDHALIDE
• Mol File: 89180-99-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 196.7±33.0 °C(Predicted)
• Appearance: /
• Density: 1.582±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1,2-Cyclopropanedicarbonyl chloride (6CI,7CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclopropanedicarbonyl chloride (6CI,7CI)(89180-99-4)
• EPA Substance Registry System: 1,2-Cyclopropanedicarbonyl chloride (6CI,7CI)(89180-99-4)

Safety Data

• Hazardous Substances Data: 89180-99-4(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Pungent

Classification

Chloroformate ester

Uses

a. Building block in organic synthesis
b. Production of pharmaceuticals and agrochemicals
c. Manufacturing of fine chemicals
d. Synthesis of cyclopropane-containing compounds
e. Medicinal chemistry and drug discovery

Reactivity

Highly reactive

Safety precautions

Handle with caution, use in well-ventilated area, wear proper personal protective equipment.

Upstream product

• 1489-58-3 trans-1,2-cyclopropanedicarboxylic acid 
• 20561-09-5 diethyl (cis,trans)-1,2-cyclopropanedicarboxylate 
• 5617-74-3 3-oxabicyclo[3.1.0]hexane-2,4-dione 
• 58616-95-8 trans-1,2-cyclopropanedicarboxylic acid 
• 3999-55-1 diethyl trans-cyclopropane-1,2-dicarboxylate 

Downstream Products

• 35974-53-9 (+/-)-trans-2-dimethylcarbamoyl-cyclopropanecarboxylic acid 
• 96149-00-7 (1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester 
• 53187-82-9 (trans-cyclopropane-1,2-diyl)dimethanol 
• 3187-76-6 (trans)-cyclopropane-1,2-diamine dihydrochloride 

Relevant articles and documents

ALKYLBORONIC ACIDS AS ARGINASE INHIBITORS

Provided are alkylboronic acids as arginase inhibitors represented by formula (I), or a pharmaceutically acceptable salt, stereoisomer, tautomer, or prodrug thereof and a pharmaceutical composition comprising said compounds.

Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors

A series of bisnaphthalimide derivatives were synthesized and evaluated for growth-inhibitory property against HT-29 human colon carcinoma. The N,N′-bis[2-(5-nitro-1,3-dioxo-2,3-dihydro-1H-benz[de]-isoquinolin- 2-yl)]propane-2-ethanediamine (9) and the N,N′-Bis[2-(5-nitro-1,3-dioxo-2,3-dihydro-1H-benz[de]-isoquinolin- 2-yl)]butylaminoethyl]-2-propanediamine (12) derivatives emerged as the most potent compounds of this series. Molecular modelling studies indicated that the high potency of 12, the most cytotoxic compound of the whole series, could be due to larger number of intermolecular interactions and to the best position of the naphthalimido rings, which favours π-π stacking interactions with purine and pyrimidine bases in the DNA active site. Moreover, 12 was designed as a DNA topoisomerase II poison and biochemical studies showed its effect on human DNA topoisomerase II. We then selected the compounds with a significant cytotoxicity for apoptosis assay. Derivative 9 was able to induce significantly apoptosis (40%) at 0.1 μM concentration, and we demonstrated that the effect on apoptosis in HT-29 cells is mediated by caspases activation.

Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia

A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as excep