20600-22-0

Basic information

• Product Name: 1-BROMO-4-(PHENOXYMETHYL)BENZENE
• Synonyms: 1-BROMO-4-(PHENOXYMETHYL)BENZENE
• CAS NO: 20600-22-0
• Molecular Formula: C₁₃H₁₁BrO
• Molecular Weight: 263.13
• Mol File: 20600-22-0.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BROMO-4-(PHENOXYMETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-4-(PHENOXYMETHYL)BENZENE(20600-22-0)
• EPA Substance Registry System: 1-BROMO-4-(PHENOXYMETHYL)BENZENE(20600-22-0)

Safety Data

• Hazardous Substances Data: 20600-22-0(Hazardous Substances Data)

Usage

Description

1-Bromo-4-(phenoxymethyl)benzene is a chemical compound that features a benzene ring with a bromine atom at the 1 position and a phenoxy group at the 4 position. It is a clear, colorless to pale yellow liquid with a strong aromatic odor. 1-BROMO-4-(PHENOXYMETHYL)BENZENE serves as a building block in organic synthesis, particularly for the production of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
1-Bromo-4-(phenoxymethyl)benzene is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-bromo-4-(phenoxymethyl)benzene is utilized as a precursor for the production of pesticides and other agrochemicals. Its versatility in organic synthesis contributes to the creation of effective solutions for agricultural challenges.
Safety Precautions:

Upstream product

• 139-02-6 sodium phenoxide 
• 589-17-3 p-bromobenzyl chloride 
• 108-95-2 phenol 
• 1122-91-4 4-bromo-benzaldehyde 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 873-75-6 4-bromobenzenemethanol 
• 66003-78-9 triphenylsulfonium trifluoromethanesulfonate 
• 98-80-6 phenylboronic acid 
• 55883-45-9 4-bromobenzyliodide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 2683-70-7 4-(phenoxymethyl)benzaldehyde 
• 855358-62-2 4-(4-bromo-benzyl)-phenol 
• 857854-96-7 2-(4-bromobenzyl)phenol 
• 29263-69-2 4-(phenoxymethyl)-1,1'-biphenyl 
• 31719-76-3 4-phenoxymethyl-benzoic acid 
• 153227-19-1 3-(4-phenoxymethylphenyl)-quinuclidin-3-ol 

Relevant articles and documents

Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors

SecA, a key component of the bacterial Sec-dependent secretion pathway, is an attractive target for the development of new antimicrobial agents. We have previously reported pyrimidine analogs as SecA inhibitors. Herein, we report an extension of the earlier work in the synthesis and evaluation of a series of 15 5-cyanothiouracil derivatives as SecA inhibitors. All the compounds have been evaluated for their inhibition of SecA ATPase (EcSecAN68) and for their antimicrobial activity against Escherichia coli NR698 (a leaky mutant) and Bacillus anthracis Sterne. Twelve compounds showed IC50 of less than 6.3 μM when tested against EcSecAN68. In antimicrobial studies against E. coli NR698, six compounds showed MIC of 12.5 μM with three being less than 6.3 μM. Against B. anthracis Sterne, three compounds showed MIC of 6.3 μM.

Developing benign syntheses using ion pairsviasolvent-free mechanochemistry

Solvent-free mechanochemical conditions have been developed to investigate the significance of ion pairing and the use of weak bases for driving forward nucleophilic substitution reactions. This approach takes advantage of the lack of solvent shells to in

Base-Mediated O-Arylation of Alcohols and Phenols by Triarylsulfonium Triflates

A mild and efficient protocol for O-arylation of alcohols and phenols (ROH) by triarylsulfonium triflates was developed under transition-metal-free conditions. Various alcohols, including primary, secondary and tertiary, and phenols bearing either electron-donating or electron-withdrawing groups on the aryl rings were smoothly converted to form the corresponding aromatic ethers in moderate to excellent yields. The reactions were conducted at 50 or 80 °C for 24 h in the presence of a certain base and showed good functional group tolerance. The base-mediated arylation with asymmetric triarylsulfonium salts could selectively transfer the aryl groups of sulfoniums to ROH, depending on their inherent electronic nature. The mechanistic studies revealed that the reaction might proceed through the nucleophilic attack of the in situ formed alkoxy or phenoxy anions at the aromatic carbon atoms of the C?S bonds of triarylsulfonium cations to furnish the target products.