20615-94-5Relevant articles and documents
POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS
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Paragraph 0180, (2017/12/09)
The disclosure provides compounds of the formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables A, R1, and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering to a patient infected with the bacteria, simultaneously or sequentially, a therapeutically effective amount of the antibacterial agent and a compound of formula (I).
Novel bi-cyclic or tri-cyclic heterocyclic compound
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Paragraph 3309 - 3311, (2016/10/07)
The present invention provides novel bi-cyclic or tri-cyclic compound represented by formula (I) or pharmaceutical acceptable salt thereof, [wherein, ring A is an aromatic group which may be substituted, one of X1 and X2 is a carbon atom, and another is a nitrogen atom, X3 is a nitrogen atom or CR2, X4 is a nitrogen atom or CR3, X5 is a sulfur atom or -CH=CH-, Z1 is an oxygen atom, -C(R6)(R7)-, -NH-, -C(R6)(R7)-NH-, -NH-C(R6)(R7)-, -C(R6)(R7)-O-, -O-C(R6)(R7)- or a single bone, one of Z2 and Z3 is CH and another one is a nitrogen atom, or both are nitrogen atoms, the other symbols are same as those defined in the specification.]