2062-74-0

Basic information

• Product Name: 1-[4-(4-fluorophenoxy)butyl]-4-(2-methoxyphenyl)piperazine
• Synonyms: 1-[4-(4-Fluorophenoxy)butyl]-4-(2-methoxyphenyl)piperazine; Piperazine, 1-[4-(4-fluorophenoxy)butyl]-4-(2-methoxyphenyl)-
• CAS NO: 2062-74-0
• Molecular Formula: C₂₁H₂₇FN₂O₂
• Molecular Weight: 358.4497
• Mol File: 2062-74-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 495.5°C at 760 mmHg
• Flash Point: 253.5°C
• Density: 1.12g/cm³
• Vapor Pressure: 5.85E-10mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 1-[4-(4-fluorophenoxy)butyl]-4-(2-methoxyphenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(4-fluorophenoxy)butyl]-4-(2-methoxyphenyl)piperazine(2062-74-0)
• EPA Substance Registry System: 1-[4-(4-fluorophenoxy)butyl]-4-(2-methoxyphenyl)piperazine(2062-74-0)

Safety Data

• Hazardous Substances Data: 2062-74-0(Hazardous Substances Data)

Upstream product

• 371-41-5 4-Fluorophenol 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 2033-80-9 1-bromo-4-(p-fluorophenoxy)butane 

Relevant articles and documents

The one-pot synthesis of butyl-1H-indol-3-alkylcarboxylic acid derivatives in ionic liquid as potent dual-acting agent for management of BPH

Based on the SAR of both α1-AR antagonists and 5α-reductase (5AR) inhibitors, the dual-acting agent 4-(1-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-1H-indol-3-yl)butanoic acid 4aaa was designed against BPH and synthesized by two steps of N-alkylation. One-pot protocol towards 4aaa was newly developed. With IL [C6min]Br as solvent, the yield of 4aaa was increased to 75.1% from 16.0% and the reaction time was shortened in 1.5 h from 48 h. 25 derivatives structurally based on arylpiperazine and indolyl butyric acid with alkyl linker were prepared. The protocol was futher extended to get another 14 derivatives wherein O-alkylation was involved, and applied to the synthesis of biologically efficient molecules DPQ and Aripiprazole. Expectedly, compound 4aaa exhibited dual inhibition of α1-AR and 5α-reductase, and exhibited no obvious cytotoxicity against human cells. The pharmacokinetic properties of 4aaa was also determined.