2033-80-9

Basic information

• Product Name: 1-(4-BROMOBUTOXY)-4-FLUOROBENZENE
• Synonyms: 1-BROMO-4-(4'-FLUOROPHENOXY)BUTANE;1-(4-BROMOBUTOXY)-4-FLUOROBENZENE;4-Fluorophenoxybutylbromide
• CAS NO: 2033-80-9
• Molecular Formula: C₁₀H₁₂BrFO
• Molecular Weight: 247.1
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Fluorine Compounds
• Mol File: 2033-80-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 195 °C (12 mmHg)
• Flash Point: 164.2°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 0.00177mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: 1-(4-BROMOBUTOXY)-4-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOBUTOXY)-4-FLUOROBENZENE(2033-80-9)
• EPA Substance Registry System: 1-(4-BROMOBUTOXY)-4-FLUOROBENZENE(2033-80-9)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/22
• Safety Statements: 37/39-26
• Hazardous Substances Data: 2033-80-9(Hazardous Substances Data)

Usage

General Description

1-(4-Bromobutoxy)-4-fluorobenzene is a chemical compound with the molecular formula C10H13BrFO. It is a derivative of benzene, with a 4-fluoro substituent and a 1-(4-bromobutoxy) side chain. 1-(4-BROMOBUTOXY)-4-FLUOROBENZENE belongs to the class of organic compounds known as bromobenzenes, which are organic compounds containing a bromine atom attached to a benzene ring. It is used in organic synthesis and research as a building block for the production of more complex organic compounds. This chemical may have potential applications in the pharmaceutical and agrochemical industries due to its versatile reactivity and structural properties. Additionally, its use in academic research may contribute to advancements in the field of organic chemistry.

InChI:InChI=1/C10H12BrFO/c11-7-1-2-8-13-10-5-3-9(12)4-6-10/h3-6H,1-2,7-8H2

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 371-41-5 4-Fluorophenol 
• 371-35-7 sodium 4-fluorophenoxide 

Downstream Products

• 1195950-20-9 C₁₁H₁₆FNO 
• 2062-74-0 1-(4-(4-fluorophenoxy)butyl)-4-(2-methoxyphenyl)piperazine 
• 1135025-53-4 2-[5-(4-fluorophenoxy)pentyl]-3-methylquinolin-4(1H)-one 
• 1566527-93-2 8-fluoro-5-(4-(4-fluorophenoxy)butyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 1566528-17-3 C₂₄H₂₆F₂N₂O₃ 
• 1417454-23-9 C₂₈H₃₁FN₂O₄ 
• 1135031-28-5 [4-(4-fluorophenoxy]butyl]triphenylphosphonium bromide 

Relevant articles and documents

Iron(II) and Copper(I) Control the Total Regioselectivity in the Hydrobromination of Alkenes

A new method that allows the complete control of the regioselectivity of the hydrobromination reaction of alkenes is described. Herein, we report a radical procedure with TMSBr and oxygen as common reagents, where the formation of the anti-Markovnikov product occurs in the presence of parts per million amounts of the Cu(I) species and the formation of the Markovnikov product occurs in the presence of 30 mol % iron(II) bromide. Density functional theory calculations combined with Fukui's radical susceptibilities support the obtained results.

Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H2O: An Expedient Way to Access Alkyl Amides

We herein describe a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanides, and H2O to access alkyl amides. Bench-stable NiCl2(dppp) is competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process is proposed based on preliminary experiments and previous literature.

Novel Carboline Derivatives as Potent Antifungal Lead Compounds: Design, Synthesis, and Biological Evaluation

A series of novel antifungal carboline derivatives was designed and synthesized, which showed broad-spectrum antifungal activity. Particularly, compound C38 showed comparable in vitro antifungal activity to fluconazole without toxicity to human embryonic lung cells. It also exhibited good fungicidal activity against both fluconazole-sensitive and -resistant Candida albicans cells and had potent inhibition activity against Candida albicans biofilm formation and hyphal growth. Moreover, C38 showed good synergistic antifungal activity in combination with fluconazole (FLC) against FLC-resistant Candida species. Preliminary mechanism studies revealed that C38 might act by inhibiting the synthesis of fungal cell wall.