20635-13-6Relevant articles and documents
Facile microwave-assisted synthesis of thioformamides from isocyanides and carbon disulfide
Abás, Sònia,Moens, Ulrike,Escolano, Carmen
, p. 2768 - 2770 (2017)
A new, fast, solvent-free and efficient method is provided to prepare thioformamides by reacting isocyanides derivatives, carbon disulfide and benzylamine under microwave irradiation.
Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent
De La Vega-Hernández, Karen,Senatore, Raffaele,Miele, Margherita,Urban, Ernst,Holzer, Wolfgang,Pace, Vittorio
supporting information, p. 1970 - 1978 (2019/02/20)
Thioformamides are easily prepared-under full chemocontrol-through the partial reduction of isothiocyanates with the in situ generated Schwartz reagent. The high electrophilicity of the starting materials enables the straightforward addition of the hydride ion, thus constituting a reliable and high-yielding method for obtaining variously functionalized thioformamides. Sensitive chemical groups to the reduction conditions such as nitro, ester, alkene, azo, azide and keto groups do not interfere with the chemoselectivity of the process. Moreover, the stereochemical information embodied in the starting material is fully retained in the final products. The synthetic potential of the selected thioformamide template is also briefly discussed.
Preparation and reactions of N-thioformyl peptides from amino thioacids and isonitriles
Yuan, Yu,Zhu, Jianglong,Li, Xuechen,Wu, Xiangyang,Danishefsky, Samuel J.
body text, p. 2329 - 2333 (2009/09/06)
The preparation of N-thioformyl peptides from amino thioacids and isonitriles at room temperature is described.
