21198-18-5

Basic information

• Product Name: 4-CYCLOHEXYL-3-THIOSEMICARBAZIDE
• Synonyms: 4-CYCLOHEXYL-3-THIOSEMICARBAZIDE;4-cyclohexylthiosemicarbazide;n-cyclohexyl-hydrazinecarbothioamid;n-cyclohexylhydrazinecarbothioamide;n-cyclohexylthiosemicarbazide;4-CHCLOHEXYLTHIOSEMICARBAZIDE;N1-cyclohexylhydrazine-1-carbothioamide;HydrazinecarbothioaMide, N-cyclohexyl-
• CAS NO: 21198-18-5
• Molecular Formula: C₇H₁₅N₃S
• Molecular Weight: 173.28
• Product Categories: Indolines ,Indoles ,Indazoles
• Mol File: 21198-18-5.mol
• Article Data: 55

Chemical Properties

• Melting Point: 142 °C
• Boiling Point: 281.3 °C at 760 mmHg
• Flash Point: 123.9 °C
• Appearance: /
• Density: 1.14 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.73±0.70(Predicted)
• CAS DataBase Reference: 4-CYCLOHEXYL-3-THIOSEMICARBAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYCLOHEXYL-3-THIOSEMICARBAZIDE(21198-18-5)
• EPA Substance Registry System: 4-CYCLOHEXYL-3-THIOSEMICARBAZIDE(21198-18-5)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 21198-18-5(Hazardous Substances Data)

Usage

Description

4-Cyclohexyl-3-thiosemicarbazide is a chemical compound belonging to the class of 4-aryl-thiosemicarbazides. It is characterized by the presence of a cyclohexyl group attached to the thiosemicarbazide structure, which contributes to its potential antimicrobial properties and utility in the synthesis of pharmaceutical products.

Uses

Used in Antimicrobial Applications:
4-Cyclohexyl-3-thiosemicarbazide is used as an antimicrobial agent due to its potential to inhibit the growth of various microorganisms, making it a valuable compound in the development of new antimicrobial drugs and treatments.
Used in Pharmaceutical Synthesis:
4-Cyclohexyl-3-thiosemicarbazide serves as an intermediate in the synthesis of pharmaceutical goods. Its unique chemical structure allows for the creation of a variety of pharmaceutical compounds with diverse applications in the medical field.
Used in Chemical Research:
As a member of the 4-aryl-thiosemicarbazides class, 4-cyclohexyl-3-thiosemicarbazide is also utilized in chemical research to explore its properties, reactivity, and potential applications in various chemical and pharmaceutical processes.

InChI:InChI=1/C7H15N3S/c8-7(11)10(9)6-4-2-1-3-5-6/h6H,1-5,9H2,(H2,8,11)

Upstream product

• 1122-82-3 isothiocyanatocyclohexane 
• 75-15-0 carbon disulfide 
• 108-91-8 cyclohexylamine 
• 5397-03-5 hydrazinecarbodithioic acid methyl ester 
• 302-01-2 hydrazine 
• 2801-07-2 monocyclohexyldithiocarbamate sodium 
• 20635-13-6 N-cyclohexylmethanethioamide 
• 7803-57-8 hydrazine hydrate 
• 701971-00-8 C₁₂H₂₃N₃O₂S 
• 690634-04-9 benzotriazole-1-carbothioic acid cyclohexylamide 
• 112864-51-4 cyclohexylthiocarbamoylsulfanyl-acetic acid 
• 66917-87-1 N-cyclohexyl(aminosulfanyl)carbothioamide 

Downstream Products

• 68161-70-6 5-(cyclohexylamino)-1,3,4-thiadiazole-2-thiol 
• 20320-02-9 cyclohexyl-[5-(dimethylamino-methyl)-[1,3,4]thiadiazol-2-yl]-amine 
• 16418-13-6 2,4-Bis-(4-cyclohexyl-thiosemicarbazono)-pentan 
• 503281-84-3 3-phenyl-propenal 4-cyclohexyl-thiosemicarbazone 
• 20158-18-3 4-dimethylamino-benzaldehyde 4-cyclohexyl-thiosemicarbazone 
• 66654-55-5 N-cyclohexyl-1,2,3,4-thiatriazol-5-amine 
• 454247-01-9 C₁₅H₁₇BrN₄OS 
• 29983-29-7 4-cyclohexyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 1084892-98-7 5-trifluoromethoxy-1H-indole-2,3-dione 3-(N-cyclohexylthiosemicarbazone) 
• 1084893-21-9 1-methyl-5-trifluoromethoxy-1H-indole-2,3-dione 3-(N-cyclohexylthiosemicarbazone) 
• 1253912-88-7 (E)-4-cyclohexyl-1-((furan-2-yl)methylene)thiosemicarbazide 
• 1240322-71-7 benzyl (1-(2-(cyclohexylcarbamothioyl)hydrazinyl)-1-oxopropan-2-yl)carbamate 
• 1240322-70-6 (S)-benzyl (1-(2-(cyclohexylcarbamothioyl)hydrazinyl)-1-oxopropan-2-yl)carbamate 
• 1240322-69-3 (S)-benzyl (1-(2-(cyclohexylcarbamothioyl)hydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate 

Relevant articles and documents

Cu(II) and Zn(II) complexes from a thiosemicarbazone derivative: Investigating the intermolecular interactions, crystal structures and cytotoxicity

Two complexes of Cu(II) and Zn(II) were prepared from a thiosemicarbazone derivative (H2esct) using their corresponding metal acetates and 2,2′-bipyridine as base. The complexes were characterized by elemental analyses, UV–visible, FT-IR and NM

Synthesis of oxadiazole-thiadiazole hybrids and their anticandidal activity

In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel oxadiazole-thiadiazole hybrid compounds

Synthesis, crystal structures, and biological evaluation of manganese(II) and nickel(II) complexes of 4-cyclohexyl-1-(1-(pyrazin-2-yl)ethylidene) thiosemicarbazide

4-Cyclohexyl-1-(1-(pyrazin-2-yl)ethylidene)thiosemicarbazide (HL) and its transition metal complexes formulated as [Mn(L)2] (1) and [Ni(L) 2] (2) have been prepared in 55-75% yield and characterized by elemental analysis, IR, MS, NMR

Synthesis and crystal structure of new monometallic and bimetallic copper(II) complexes with N-substituted isatin thiosemicarbazone ligands: Effects of the complexes on DNA/protein-binding property, DNA cleavage study and in vitro anticancer activity

A novel series of N-substituted isatin thiosemicarbazone ligands (L1–L3) and their copper(II) complexes [Cu(II)(ITSC)] were synthesized and characterized by elemental analyses and UV–Vis, FT-IR,1H &13C NMR/EPR and mass spectroscopic

Synthesis and spectroscopic characterization of organotin(IV) complexes with 2-benzoylpyridine-N(4)-cyclohexylthiosemicarbazone (HBPCT): X-ray crystal structure of [PhSnCl2(BPCT)]

The reaction of 2-benzoylpyridine-N(4)-cyclohexylthiosemicarbazone [HBPCT, (1)] ligand with organotin(IV) chloride(s) lead to the formation of three new organotin(IV) complexes: [MeSnCl2(BPCT)] (2), [PhSnCl 2(BPCT)] (3) and [Ph2

Synthesis, crystal structures and biological activities of 2-acetylpyridine N(4)-cyclohexylthiosemicarbazone and its manganese(II) and nickel(II) complexes

2-Acetylpyridine N(4)-cyclohexylthiosemicarbazone (HL) and its manganese(II) and nickel(II) complexes formulated as [Mn(L)2] (1) and [Ni(L)2] (2) have been synthesized and characterized by elemental analysis, infrared spectra, mass s

Synthesis and characterization of tin(IV)/organotin(IV) complexes with 2-benzoylpyridine-N(4)-cyclohexylthiosemicarbazone [HBPCT]: X-ray crystal structure of [SnCl3(BPCT)]

Four new tin(IV)/organotin(IV) complexes, [SnCl3(BPCT)] (2), [MeSnCl2(BPCT)] (3), [Me2SnCl(BPCT)] (4), and [Ph2SnCl(BPCT)] (5), have been synthesized by the direct reaction of 2-benzoylpyridine-N(4)- cyclohexylthiosemicarbazone [HBPCT, (1)] and

Synthesis, structural, and spectral studies of diorganotin(IV) complexes with 2-hydroxy-5-methylbenzaldehyde-N (4)-cyclohexylthiosemicarbazone

Three new diorganotin(IV) complexes, [Me2Sn(L)] (2), [Bu2Sn(L)] (3), and [Ph2Sn(L)] (4) [where H2L (1) = 2-hydroxy-5-methylbenzaldehyde-N(4)-cyclohexylthiosemicarbazone] have been synthesized by reacting the cor

Experimental and theoretical studies of novel hydroxynaphthalene based chemosensor, and construction of molecular logic gates

2-Hydroxynaphthalenyl-N(4)-cyclohexyl thiosemicarbazone (CHNT) was synthesized and characterized for selective sensing of fluoride, cyanide and copper ions. The interaction between CHNT with fluoride, cyanide and copper ions have been investigated through

CERTAIN NEW 4-(2-((5-(SUBSTITUTEDAMINO)-1,3,4-THIADIAZOLE-2-YL)THIO)ACETYL)BENZENESULPHONEAMIDE DERIVATIVES AND A METHOD FOR THE SYNTHESIS OF SAID DERIVATIVES

The invention relates to a certain new 4-(2-((5-(substitutedamino)-1,3,4-thiadiazole-2-yl)thio)acetyl)benzenesulphonamide derivatives for use in pharmaceutics, chemical and pharmaceutical industry, and to a method for the synthesis of said derivatives.

Diaryl-substituted thiosemicarbazone: A potent scaffold for the development of New Delhi metallo-β-lactamase-1 inhibitors

The superbug infection caused by New Delhi metallo-β-lactamase (NDM-1) has become an emerging public health threat. Inhibition of NDM-1 has proven challenging due to its shuttling between pathogenic bacteria. A potent scaffold, diaryl-substituted thiosemicarbazone, was constructed and assayed with metallo-β-lactamases (MβLs). The obtained twenty-six molecules specifically inhibited NDM-1 with IC50 0.038–34.7 μM range (except 1e, 2e, and 3d), and 1c is the most potent inhibitor (IC50 = 0.038 μM). The structure-activity relationship of synthetic thiosemicarbazones revealed that the diaryl-substitutes, specifically 2-pyridine and 2-hydroxylbenzene improved inhibitory activities of the inhibitors. The thiosemicarbazones exhibited synergistic antimycobacterial actions against E. coli-NDM-1, resulted a 2–512-fold reduction in MIC of meropenem, while 1c restored 16–256-, 16-, and 2-fold activity of the antibiotic on clinical isolates ECs, K. pneumonia and P. aeruginosa harboring NDM-1, respectively. Also, mice experiments showed that 1c had a synergistic antibacterial ability with meropenem, reduced the bacterial load clinical isolate EC08 in the spleen and liver. This work provided a highly promising scaffold for the development of NDM-1 inhibitors.