2066-88-8

Basic information

• Product Name: NSC 407340
• Synonyms: 2,6-Dioxo-4-piperidineacetaldehyde;3-(ForMylMethyl)glutariMide;NSC 407340;4-Piperidineacetaldehyde, 2,6-dioxo-
• CAS NO: 2066-88-8
• Molecular Formula: C₇H₉NO₃
• Molecular Weight: 155.15126
• Product Categories: Heterocycles, Intermediates
• Mol File: 2066-88-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 122-123 °C(Solv: acetone (67-64-1); hexane (110-54-3))
• Boiling Point: 369.3°Cat760mmHg
• Flash Point: 181.2°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 1.2E-05mmHg at 25°C
• Refractive Index: 1.467
• PKA: 11.42±0.40(Predicted)
• CAS DataBase Reference: NSC 407340(CAS DataBase Reference)
• NIST Chemistry Reference: NSC 407340(2066-88-8)
• EPA Substance Registry System: NSC 407340(2066-88-8)

Safety Data

• Hazardous Substances Data: 2066-88-8(Hazardous Substances Data)

Usage

Description

NSC 407340, also known as 3-(Formylmethyl)glutarimide, is a glutaramide derivative with potential antiviral properties. It is a synthetic compound that has been studied for its ability to inhibit viral replication and protect cells from viral infections.

Uses

Used in Pharmaceutical Industry:
NSC 407340 is used as an antiviral agent for the development of antiviral drugs. It is particularly effective against a wide range of viruses, including herpes simplex virus, influenza virus, and human immunodeficiency virus (HIV). NSC 407340 works by interfering with the viral replication process, thereby preventing the spread of the virus and reducing the severity of the infection.
NSC 407340 is also used in the research and development of new antiviral therapies. Its unique structure and mechanism of action make it a valuable tool for understanding the molecular basis of viral infections and for designing more effective treatments.
In addition to its direct antiviral activity, NSC 407340 has potential applications in other areas of medicine, such as immunology and oncology, due to its ability to modulate cellular processes and interact with various biological targets. However, further research is needed to fully explore these possibilities and to optimize the compound's therapeutic potential.

InChI:InChI=1/C7H9NO3/c9-2-1-5-3-6(10)8-7(11)4-5/h2,5H,1,3-4H2,(H,8,10,11)

Upstream product

• 6258-28-2 (2,6-dioxopiperidin-4-yl)acetic acid 
• 1149347-46-5 3-[(dodecylthio-carbonyl)-methyl]-glutarimide 
• 772-50-9 (2,6-dioxo-piperidin-4-yl)-acetyl chloride 

Downstream Products

• 15407-96-2 4-[4-(2,6-dioxo-piperidin-4-ylmethyl)-2-morpholin-4-yl-6-(4-nitro-phenyl)-3,4-dihydro-2H-pyran-3-yl]-piperidine-2,6-dione 
• 298213-33-9 4-{2-[3,5-dimethyl-2-(tetrahydro-pyran-2-yloxy)-phenyl]-2-hydroxy-ethyl}-piperidine-2,6-dione 
• 1267512-90-2 4-(2-hydroxy-4-oxo-5-o-tolylhexyl)piperidin-2,6-dione 
• 1267512-85-5 4-(2-hydroxy-4-oxo-5-o-tolylpentyl)piperidin-2,6-dione 
• 15366-95-7 4-[4-(2,6-dioxo-piperidin-4-ylmethyl)-2-hydroxy-6-(4-nitro-phenyl)-3,4-dihydro-2H-pyran-3-yl]-piperidine-2,6-dione 
• 298213-39-5 4-[2-(2-benzyloxymethoxy-3,5-dimethyl-phenyl)-1,2-dihydroxy-ethyl]-1-benzyloxymethyl-piperidine-2,6-dione 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 738-72-7 streptimidone 

Relevant articles and documents

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring

Migrastatin and isomigrastatin analogues have been synthesised in order to contribute to structure-activity studies on tumour cell migration inhibitors. These include macrocycles varying in ring size, functionality and alkene stereochemistry, as well as glucuronides. The synthesis work included application of the Saegusa-Ito reaction for regio- and stereoselective unsaturated macroketone formation, diastereoselective Brown allylation to generate 9-methylmigrastatin analogues and chelation-induced anomerisation to vary glucuronide configuration. Compounds were tested in vitro against both breast and pancreatic cancer cell lines and inhibition of tumour cell migration was observed in both wound-healing (scratch) and Boyden chamber assays. One unsaturated macroketone showed low affinity for a range of secondary drug targets, indicating it is at low risk of displaying adverse side effects.

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Synthesis and antiviral activities of synthetic glutarimide derivatives

A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (Cox B3), 10 and 6f against influenza vi

MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF

In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-RC, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.