2069-54-7

Basic information

• Product Name: bis(4-fluorophenyl)diazomethane
• Synonyms: bis(4-fluorophenyl)diazomethane
• CAS NO: 2069-54-7
• Molecular Weight: 230.217
• Mol File: 2069-54-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: bis(4-fluorophenyl)diazomethane(CAS DataBase Reference)
• NIST Chemistry Reference: bis(4-fluorophenyl)diazomethane(2069-54-7)
• EPA Substance Registry System: bis(4-fluorophenyl)diazomethane(2069-54-7)

Safety Data

• Hazardous Substances Data: 2069-54-7(Hazardous Substances Data)

Upstream product

• 837-69-4 4,4'-difluorobenzophenone hydrazone 
• 345-92-6 4,4'-Difluorobenzophenone 
• 80-70-6 N,N,N',N'-tetramethylguanidine 

Downstream Products

• 435-08-5 1,1,2,2-tetrakis(4-fluoroophenyl)ethylene 
• 365-24-2 4,4'-difluorobenzhydryl alcohol 

Relevant articles and documents

Copper-Mediated Cross-Coupling of Diazo Compounds with Sulfinates

A copper-mediated cross-coupling reaction between a diazo compound and a sodium alkane(arene)sulfinate gives a sulfone as the product. This reaction proceeds under mild conditions and features excellent functional group compatibility. A wide range of sodium alkane(arene)sulfinates were successfully applied in this chemistry. Mechanistic studies revealed that the overall reaction efficiency of the sulfinates was in line with their nucleophilicity in this reaction.

Direct α-Monofluoroalkenylation of Heteroatomic Alkanes via a Combination of Photoredox Catalysis and Hydrogen-Atom-Transfer Catalysis

In this study, a new C(sp3)-H monofluoroalkenylation reaction involving cooperative visible-light photoredox catalysis and hydrogen-atom-transfer catalysis to afford products generated by selective hydrogen abstraction and radical-radical cross-coupling was described. This mild, efficient reaction shows high regioselectivity for the α-carbon atoms of amines, ethers, and thioethers and thus allows the preparation of monofluoroalkenes bearing various substituents. The reaction was applied to two bioactive molecules, indicating its utility for late-stage monofluoroalkenylation of compounds with inert C(sp3)-H bonds.

Visible light photocatalytic decarboxylative monofluoroalkenylation of α-amino acids with: Gem -difluoroalkenes

α-Amino acids are among the most common biologically active molecules in nature, and their functionalization has attracted much attention. In this communication, a novel, efficient and general visible-light photocatalytic decarboxylative monofluoroalkenylation of N-protected α-amino acids with gem-difluoroalkenes is reported, affording the corresponding α-amino monofluoroalkenes which might find applications in medical chemistry and materials science. The reaction proceeded at room temperature with high efficiency and tolerance of various functional groups.