207446-83-1

Basic information

• Product Name: Arteannuin H
• CAS NO: 207446-83-1
• Molecular Weight: 250.338
• Mol File: 207446-83-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Arteannuin H(CAS DataBase Reference)
• NIST Chemistry Reference: Arteannuin H(207446-83-1)
• EPA Substance Registry System: Arteannuin H(207446-83-1)

Safety Data

• Hazardous Substances Data: 207446-83-1(Hazardous Substances Data)

Upstream product

• 85031-60-3 4α-hydroperoxy-amorph-5-en-12-oic acid 
• 85031-59-0 dihydroartemisinic acid 

Relevant articles and documents

METHOD AND DEVICE FOR THE SYNTHESIS OF ARTEMISININ

The present invention is directed to a method for producing artemisinin having the formula (6) from dihydroartennisinic acid in a continuous flow reactor using singlet oxygen as well as to the continuous flow reactor for producing artemisinin.

The mechanism of the spontaneous autoxidation of dihydroartemisinic acid

Dihydroartemisinic acid undergoes slow spontaneous autoxidation to artemisinin and other natural products, which have been reported from the medicinal plant Artemisia annua. The mechanism of this complex transformation is shown to involve four steps: (i) initial reaction of the Δ4.5-double bond of dihydroartemisinic acid with molecular oxygen, (ii) Hock cleavage of the resulting tertiary allylic hydroperoxide; (iii) oxygenation of the enol product from Hock cleavage; and (iv) cyclization of the resulting vicinal hydroperoxyl-aldehyde to the 1,2,4-trioxane system of artemisinin.