207558-19-8

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 9H-fluoren-9-ylmethyl ester
• Synonyms: Piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester;9-fluorenylmethoxycarbonylpiperidine;1-(9-Fluorenylmethoxycarbonyl)piperidine;N-(9-fluorenylmethoxycarbonyl)piperidine
• CAS NO: 207558-19-8
• Molecular Formula: C20H21NO2
• Molecular Weight: 307.392
• Mol File: 207558-19-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 121 °C (diethyl ether)
• Boiling Point: 466.3±14.0 °C(Predicted)
• Density: 1.184±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 9H-fluoren-9-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 9H-fluoren-9-ylmethyl ester(207558-19-8)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 9H-fluoren-9-ylmethyl ester(207558-19-8)

Safety Data

• Hazardous Substances Data: 207558-19-8(Hazardous Substances Data)

Usage

Synonyms

Fluoren-9-ylmethyl piperidine-1-carboxylate
Different names used to refer to the same compound.
3. Use in organic synthesis and pharmaceutical research
A key component in creating various medicinal and pharmacological agents.
4. Derivative of piperidine and fluorene
A compound formed by modifying the structures of piperidine and fluorene.

Molecular structure

Piperidine ring attached to a fluorenyl group
The arrangement of atoms in the compound, consisting of a five-membered nitrogen-containing ring and a large aromatic ring.

Building block in synthesis

Medicinal and pharmacological agents
A starting material used to create various drugs and medications.

Potential as a starting material

Novel bioactive compounds
Its unique structure makes it suitable for producing new compounds with potential biological activity.
8. Importance in drug discovery and development
Contributes to the creation of new drugs and therapies by serving as a key intermediate in their synthesis.

Value in medicinal chemistry and drug design

Unique structure and properties
Its distinct molecular arrangement and characteristics make it a useful tool for researchers in the field of medicinal chemistry.

Upstream product

• 209115-33-3 5-amino-N-[(9H-fluoren-9-yl)methoxycarbonyl]pentan-1-ol 
• 2508-29-4 5-hydroxypentylamine 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 110-89-4 piperidine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 35661-40-6 N-Fmoc L-Phe 
• 134939-09-6 VO(OCH₂CH(CH₃)2)2(O(CH₂)6NH(C₁₃H₉CH₂OCO)) 
• 909114-66-5 9-fluorenylmethyl 4,6-dimethoxy-1,3,5-triazinyl carbonate 
• 511244-41-0 N-(9-fluorenylmethoxycarbonyl)-5,7-dinitroindoline 

Downstream Products

• 110-89-4 piperidine 
• 124-38-9 carbon dioxide 
• 4425-82-5 9-methylene-fluorene 

Relevant articles and documents

Orthoester in Cyclodehydration of Carbamate-Protected Amino Alcohols under Acidic Conditions

The first acid-promoted reaction system to form azaheterocycles from N -carbamate-protected amino alcohols is described. The reaction involves the activation of the hydroxyl group via the use of orthoesters. Despite the reduced nucleophilicity of carbamate nitrogen, this reaction system provides several types of pyrrolidines and piperidines in good to high yields. Using this protocol, prolinol derivatives can also be synthesized from carbamate-protected amino diols with regio- and stereoselectivity.

N-Urethane protection of amines and amino acids in an ionic liquid

An efficient, solvent-free protocol for the N-fluorenylmethoxycarbonylation and N-benzyloxycarbonylation of amines is described. The reaction of aliphatic and aromatic amines with FmocOSu and Cbz-Osu in [Bmim][BF4] at room temperature afforded the corresponding N-urethane derivatives in excellent yields and do not require any further purification. The method has been extended to the N-Fmoc and N-Cbz protection of amino acids. Absence of bases, very short reaction times, high yields, selectivity and ease of product separation are some advantages of this protocol.

ANTIMICROBIAL AGENTS BASED ON HEMIN DERIVATIVES

The invention relates to novel antimicrobial, including antibacterial and antifungal, agents and compositions based on hemin derivatives of general formula (I), and also to the production of novel hemin derivatives. The advantages of antibacterial agents based on hemin derivatives are their biocompatibility, biodegradability, high effectiveness against resistant bacteria and widespread microfungi that are harmful to humans, and freedom from toxicity and side effects.