209115-33-3

Basic information

• Product Name: 5-(FMOC-AMINO)-1-PENTANOL
• Synonyms: 5-(Fmoc-amino)-1-pentanol≥ 95% (NMR);5-Fmoc-Ava-ol;Carbamic acid,N-(5-hydroxypentyl)-, 9H-fluoren-9-ylmethyl ester
• CAS NO: 209115-33-3
• Molecular Formula: C₂₀H₂₃NO₃
• Molecular Weight: 325.4
• Mol File: 209115-33-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 103-108 °C (dec.)
• Boiling Point: 530.3±33.0 °C(Predicted)
• Appearance: /
• Density: 1.169±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.26±0.46(Predicted)
• CAS DataBase Reference: 5-(FMOC-AMINO)-1-PENTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(FMOC-AMINO)-1-PENTANOL(209115-33-3)
• EPA Substance Registry System: 5-(FMOC-AMINO)-1-PENTANOL(209115-33-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 209115-33-3(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 2508-29-4 5-hydroxypentylamine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Downstream Products

• 207558-19-8 1-(9-Fluorenylmethoxycarbonyl)piperidine 
• 1609107-77-8 9H-fluoren-9-ylmethyl [5-(4-acetylphenoxy)pentyl]carbamate 
• 1440540-80-6 C₄₉H₅₆N₄O₁₈ 
• 129185-29-1 5-amino-O-(4,4'-dimethoxytrityl)pentan-1-ol 
• 952661-11-9 2-benzyl-3-[{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-piperidinyl}(hydroxy)phosphoryl]propanoic acid 
• 952661-17-5 2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-piperidinyl}phosphinic acid 

Relevant articles and documents

Synthesis and Structural Elucidation of 1,2-Disubstituted 3-Fluoropiperidines

The work described details the reaction between Selectfluor and a series of 1-carbonyloxy and 1-sulfonyl 2-piperidines in order to generate 3-fluoro-2-methoxypiperidines 3a–f. Their subsequent reaction with allyltrimethylsilane, in the presence of BF3 and TiCl4, is then reported. Studies involving a combination of single-crystal X-ray crystallography and NMR spectroscopy indicate that the allylation process is cis-selective for both carbamate and sulfonamide variants and that optimal levels of diastereoselectivity are obtained using the N-2-nitrobenzene sulfonyl (2-Ns) group. In this manner, the synthesis of a series of 2-allyl 3-fluoro-substituted piperidines (5a, c–f) was achieved. The conversion of both the cis and trans-N-tosyl adducts (5d) into 3-fluorinated analogues of the natural products pelletierine (10) and coniine (11) is subsequently detailed.

A facile synthesis of ω-aminoalkyl ammonium hydrogen phosphates

A series of ω-aminoalkyl ammonium hydrogen phosphates were synthesized through a simple and efficient three-step method. The starting materials, ω-aminoalkyl alcohols (AC-n, with carbon number n = 3, 4, 5, 6), were amino-protected with 9-fluorenylmethyl chloroformate (Fmoc-Cl), followed by phosphorylation with POCl3 and deprotection in piperidine/DMF. The structures of each intermediate and final product were confirmed by 1H NMR, FTIR and mass spectrum. The yield of each step was about 77-92%, with a total yield higher than 56%. This new method was superior in low-cost raw materials, mild reaction temperatures (0-25°C) and easy purification methods.

Preparation of high-loading polymer supports by polymerization reaction useful for oligonucleotide synthesis

A simple protocol based on polymerization reactions has been developed for the preparation of high-loading polymer supports, useful for large-scale synthesis of oligonucleotides. Polymer supports of different pore sizes have been employed in the present i