208188-23-2

Basic information

• Product Name: 4-(tert-Butyl)-N-methoxy-N-methylbenzamide
• Synonyms: 4-(tert-Butyl)-N-methoxy-N-methylbenzamide
• CAS NO: 208188-23-2
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.29546
• Mol File: 208188-23-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 68-70
• Boiling Point: 342.5±21.0 °C(Predicted)
• Appearance: /
• Density: 1.016±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(tert-Butyl)-N-methoxy-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(tert-Butyl)-N-methoxy-N-methylbenzamide(208188-23-2)
• EPA Substance Registry System: 4-(tert-Butyl)-N-methoxy-N-methylbenzamide(208188-23-2)

Safety Data

• Hazardous Substances Data: 208188-23-2(Hazardous Substances Data)

Usage

General Description

4-(tert-Butyl)-N-methoxy-N-methylbenzamide is a chemical compound with the molecular formula C13H19NO2. It is a derivative of benzamide, containing a tert-butyl group and a methoxy group attached to the nitrogen atom. 4-(tert-Butyl)-N-methoxy-N-methylbenzamide is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized in the production of dyes, pigments, and other organic compounds. The presence of the tert-butyl and methoxy groups contributes to the compound's stability and functionality, making it valuable for a range of industrial applications. Additionally, it is important to handle this chemical with care and follow proper safety precautions due to its potential hazards.

Upstream product

• 1710-98-1 p-tert-butyl benzoyl chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 192436-83-2 4-bromo-N-methoxy-N-methylbenzamide 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 247018-51-5 4-t-butylphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 13939-06-5 molybdenum hexacarbonyl 
• 15226-74-1 dicobalt octacarbonyl 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 347346-94-5 1-(4-tert-Butylphenyl)-3-(dimethylamino)propan-1-one 
• 121149-70-0 1-[4-(1,1-dimethylethyl)phenyl]-2-phenylethanone 
• 545394-17-0 C₁₇H₂₄O₃ 
• 50807-17-5 1‐(4‐tert‐butylphenyl)‐2,2‐dichloroethan‐1‐one 
• 936078-06-7 2,2‐dibromo‐1‐(4‐tert‐butylphenyl)ethan‐1‐one 
• 39528-62-6 3-(4-tert-butylphenyl)-3-oxopropanenitrile 

Relevant articles and documents

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.

Iminyl Radicals by Reductive Cleavage of N-O Bond in Oxime Ether Promoted by SmI2: A Straightforward Synthesis of Five-Membered Cyclic Imines

A new generation method of N-centered radicals from the reductive cleavage of the N-O bond in oxime ether promoted by SmI2 is reported for the first time. The in-situ-generated N-centered radicals underwent intramolecular cyclization to afford five-membered cyclic imines in two manners: N-centered radical addition and N-centered anion nucleophilic substitution. From a synthetic point of view, an efficient synthetic method of five-membered cyclic imines was developed. A mechanism of the transformation was proposed.

Enabling the Cross-Coupling of Tertiary Organoboron Nucleophiles through Radical-Mediated Alkyl Transfer

The construction of quaternary centers is a common challenge in the synthesis of complex materials and natural products. Current cross-coupling strategies that can be generalized for setting these centers are sparse and, when known, are typically predicated on the use of reactive organometallic reagents. To address this shortcoming a new, photoredox-Ni dual catalytic strategy for the cross-coupling of tertiary organoboron reagents with aryl halides is reported. In addition to details on the cross-coupling scope and limitations, full screening efforts and mechanistic experiments are communicated.