2084-92-6Relevant articles and documents
Cold microwave chemistry: synthesis using pre-cooled reagents
Bose, Ajay K.,Ganguly, Subhendu N.,Manhas, Maghar S.,He, William,Speck, Jeffrey
, p. 3213 - 3215 (2006)
A novel experimental procedure for chemical reactions has been devised that involves mixing and then freezing the reagents (organic solvent-free) to a sub-zero temperature such as -30 °C. This frozen mixture is exposed to microwave irradiation for a brief period of time. The use of pre-cooled reagents may give a single product not obtained by traditional microwave irradiation at room temperature. Interestingly, such a product may provide information about mechanisms by identifying the first step of a multiple step reaction.
Microwave promoted rapid nitration of phenolic compounds with calcium nitrate
Bose, Ajay K.,Ganguly, Subhendu N.,Manhas, Maghar S.,Rao, Sheetal,Speck, Jeffrey,Pekelny, Uri,Pombo-Villars, Esteban
, p. 1885 - 1888 (2006)
Highly accelerated and safe nitration of phenolic compounds has been found to be feasible with a mixture of calcium nitrate and acetic acid as an efficient nitration agent under brief microwave irradiation. This method is compatible with the green chemistry approach because calcium salts-the inorganic byproducts-can be useful agrochemicals rather than waste chemicals. Commercially available 15N-labeled calcium nitrate is convenient for the preparation of 15N-labeled compounds for metabolic studies and mass spectrometry. This safe nitration method can be included in laboratory experiments for high school and college students.
