208402-14-6

Basic information

• Product Name: 2-<(Z)-3-(benzylamino)-3-oxo-1-propenyl>phenyl acetate
• Synonyms: 2-<(Z)-3-(benzylamino)-3-oxo-1-propenyl>phenyl acetate
• CAS NO: 208402-14-6
• Molecular Weight: 295.338
• Mol File: 208402-14-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-<(Z)-3-(benzylamino)-3-oxo-1-propenyl>phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<(Z)-3-(benzylamino)-3-oxo-1-propenyl>phenyl acetate(208402-14-6)
• EPA Substance Registry System: 2-<(Z)-3-(benzylamino)-3-oxo-1-propenyl>phenyl acetate(208402-14-6)

Safety Data

• Hazardous Substances Data: 208402-14-6(Hazardous Substances Data)

Upstream product

• 185995-96-4 (Z)-2-(3-(tert-butyldimethylsilyloxy)propenyl)phenol 
• 208401-84-7 Acetic acid 2-[(Z)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-phenyl ester 
• 208402-01-1 1-((Z)-3-oxo-1-propenyl)phenyl acetate 
• 91-64-5 coumarin 
• 14864-24-5 (Z)-2-(3-hydroxyprop-1-en-1-yl)phenol 
• 190366-79-1 (E)-N-Benzyl-3-(2-hydroxy-phenyl)-acrylamide 
• 61547-40-8 3-(2-acetyloxyphenyl)propynoic acid 
• 16635-92-0 3-(2-hydroxyphenyl)propynoic acid 
• 496-41-3 Benzofuran-2-carboxylic acid 
• 614-60-8 o-Coumaric acid 
• 224432-86-4 2-<3-(benzylamino)-3-oxo-1-propynyl>phenyl acetate 
• 16189-10-9 (E)-3-<2-(acetyloxy)phenyl>-2-propenoic acid 
• 100-46-9 benzylamine 
• 19878-96-7 (Z)-3-<2-(acetyloxy)phenyl>-2-propenoic acid 

Downstream Products

• 91-64-5 coumarin 

Relevant articles and documents

Two new improved approaches to the synthesis of coumarin-based prodrugs

Our laboratory has recently reported the development of a coumarin- based, esterase-sensitive prodrug system for the preparation of prodrugs of amines, peptides, and peptidomimetics. Biological evaluations including animal studies have demonstrated the cl

Chemical feasibility studies of a potential coumarin-based prodrug system

By using model amines, several amides of coumarinic acid with the phenolic hydroxyl group protected as an ester were prepared. These model amides underwent a facile (t( 1/2 ) 1.5-31 min) lactonization to release the original amine compounds upon esterase catalyzed hydrolysis of the phenolic ester. Such a system can be used for the preparation of esterase-sensitive prodrugs of amine-containing compounds or peptids.