16189-10-9

Basic information

• Product Name: 2-ACETOXYCINNAMIC ACID
• Synonyms: O-ACETYLCOUMARIC ACID;O-ACETOXYCINNAMIC ACID;2-ACETOXYCINNAMIC ACID;2-ACETYLCOUMARIC ACID;(E)-3-(2-Acetoxy-phenyl)-acrylic acid
• CAS NO: 16189-10-9
• Molecular Formula: C₁₁H₁₀O₄
• Molecular Weight: 206.19
• Mol File: 16189-10-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 367.5°Cat760mmHg
• Flash Point: 145.4°C
• Appearance: /
• Density: 1.267g/cm³
• Vapor Pressure: 4.75E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 2-ACETOXYCINNAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETOXYCINNAMIC ACID(16189-10-9)
• EPA Substance Registry System: 2-ACETOXYCINNAMIC ACID(16189-10-9)

Safety Data

• Hazardous Substances Data: 16189-10-9(Hazardous Substances Data)

Usage

General Description

2-ACETOXYCINNAMIC ACID, also known as O-Acetylsalicylic acid, is a chemical compound with the molecular formula C11H10O4. It is an ester of salicylic acid and acetic acid, and is commonly used as a precursor in the synthesis of various pharmaceutical compounds. 2-ACETOXYCINNAMIC ACID has been found to exhibit anti-inflammatory and analgesic properties, and has been studied for its potential use in the treatment of various medical conditions such as arthritis and cardiovascular disease. Additionally, 2-ACETOXYCINNAMIC ACID has also been investigated for its potential use in the field of organic chemistry as a building block for the synthesis of various organic compounds. Overall, this chemical compound has shown promise in the fields of medicine and organic chemistry for its potential therapeutic and synthetic applications.

InChI:InChI=1/C11H10O4/c1-8(12)15-10-5-3-2-4-9(10)6-7-11(13)14/h2-7H,1H3,(H,13,14)/b7-6-

Upstream product

• 90563-74-9 2-hydroxy-trans-cinnamic acid amide 
• 108-24-7 acetic anhydride 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 5663-67-2 2-acetoxybenzaldehyde 
• 90-02-8 salicylaldehyde 
• 614-60-8 o-Coumaric acid 

Downstream Products

• 614-60-8 o-Coumaric acid 
• 64-19-7 acetic acid 
• 91-64-5 coumarin 
• 208402-14-6 2-<(Z)-3-(benzylamino)-3-oxo-1-propenyl>phenyl acetate 
• 566202-08-2 2-acetoxycinnamic anhydride 
• 20996-40-1 (E)‐2‐(3‐chloro‐3‐oxoprop‐1‐en‐1‐yl)phenyl acetate 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR OCULAR DELIVERY

The present invention provides new prodrags of Sunitinib, Brinzolamide, and Dorzolamide and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (TOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.

Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure

Ten new cinnamic acid derivatives containing a 2-aminothiazole substructure were designed and synthesized. This series of compounds exhibited good thermostabilities as demonstrated by thermogravimetric analysis. In coagulation assays (prothrombin time, activated partial thromboplastin time and thrombin time) in vitro, most compounds demonstrated excellent activities to promote blood coagulation. Among the studied series, compounds N1, N4, N5 and W5 exhibited a significant coagulation activity. Further studies indicated that compound N5 (IC50 = 1.87 μmol/L) displayed the most suitable efficacy of promoting platelet aggregation than the clinically used haemostatic drug etamsylate (IC50 = 46.22 μmol/L). Furthermore, the relationship between the functional groups of the compounds and the corresponding blood coagulant activity was explored in this study.

Novel enzymatic synthesis of 4-O-cinnamoyl quinic and shikimic acid derivatives

The first direct synthesis of 4-O-cinnamoyl derivatives of quinic and shikimic acids were accomplished by regioselective esterification with Candida antarctica lipase A. For hydrocinnamic esters, enzymatic transesterification with vinyl esters gave excell