20846-04-2

Basic information

• Product Name: (N-phenyl)di-p-tolylphosphinic amide
• Synonyms: (N-phenyl)di-p-tolylphosphinic amide
• CAS NO: 20846-04-2
• Molecular Weight: 321.359
• Mol File: 20846-04-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (N-phenyl)di-p-tolylphosphinic amide(CAS DataBase Reference)
• NIST Chemistry Reference: (N-phenyl)di-p-tolylphosphinic amide(20846-04-2)
• EPA Substance Registry System: (N-phenyl)di-p-tolylphosphinic amide(20846-04-2)

Safety Data

• Hazardous Substances Data: 20846-04-2(Hazardous Substances Data)

Upstream product

• 4294-57-9 para-methylphenylmagnesium bromide 
• 1084-11-3 bis(4-methylphenyl)phosphinic acid 
• 4129-40-2 di(p-tolyl)phosphinic chloride 
• 62-53-3 aniline 

Downstream Products

• 1084-11-3 bis(4-methylphenyl)phosphinic acid 
• 62-53-3 aniline 

Relevant articles and documents

Hydrolysis of Diarylphosphinic Amides in Acidic Solution: Steric Inhibition and Mechanism

The pseudo-first-order rate constants for the hydrolysis of diphenylphosphinic amide Ph2P(O)NH2 and its di-p-tolyl, di-o-tolyl, and dimesityl analogues (106kψ 3 630, 2 340, 81.0, and 3.27 s-1 respectively with H(1+) 0.0662M and T 30.2 deg C) in water-dioxan (9:1 v/v) containing perchloric acid show that reaction is sterically hindered by ortho-methyl substituents in the P-aryl groups.Steric inhibition is as great, or greater, in the hydrolysis of the corresponding (N-phenyl)diarylphosphinic amides (106kψ 5 440, 4 470, 54.9 and 0.88 s-1 respectively with H(1+) 1.36M and T 39.9 deg C) and (N-p-nitrophenyldiarylphosphinic amides (106kψ 724, 702, 6.57, and 0.098 s-1 respectively with H(1+) 2.58M and T 39.9 deg C) even though the departing amine is less nucleophilic.Such sensitivity to steric hindrance is consistent with associative (A2) mechanism for the hydrolysis of all the substrates.