4129-40-2

Basic information

• Product Name: Di(p-tolyl)phosphinoyl chloride
• Synonyms: Di(p-tolyl)phosphinoyl chloride
• CAS NO: 4129-40-2
• Molecular Formula: C₁₄H₁₄ClOP
• Molecular Weight: 0
• Mol File: 4129-40-2.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Di(p-tolyl)phosphinoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Di(p-tolyl)phosphinoyl chloride(4129-40-2)
• EPA Substance Registry System: Di(p-tolyl)phosphinoyl chloride(4129-40-2)

Safety Data

• Hazardous Substances Data: 4129-40-2(Hazardous Substances Data)

Upstream product

• 4294-57-9 para-methylphenylmagnesium bromide 
• 762-04-9 phosphonic acid diethyl ester 
• 2409-61-2 di(p-tolyl)phosphine oxide 
• 106-38-7 para-bromotoluene 
• 1019-71-2 chlorodi-p-tolylphosphane 
• 1084-11-3 bis(4-methylphenyl)phosphinic acid 

Downstream Products

• 80717-30-2 O-(di-p-tolylphosphinyl)acetone oxime 
• 100165-87-5 2,2'-bis(di-p-tolylphosphino)-1,1'-binaphthyl dioxide 
• 20846-04-2 (N-phenyl)di-p-tolylphosphinic amide 
• 41044-89-7 di(4-tolyl)phosphinic acid butyl ester 
• 102767-83-9 Di-p-tolyl-phosphinic acid p-tolyl ester 
• 102767-82-8 o-phenyl 4-methylphenyl(4-methylphenyl)phosphinate 
• 124730-87-6 trimethylammonio-N-(di-p-tolylphosphinoyl)imide 
• 124730-96-7 N-(dimethylaminomethyl)di-p-tolylphosphinic amide 
• 124730-88-7 1,1,1-trimethyl-2-(di-p-tolylphosphinoyl)hydrazinium iodide 
• 1590442-13-9 C₂₀H₁₅F₅NOP 
• 1590442-52-6 C₂₇H₁₈F₈NOP 

Relevant articles and documents

Microwave-Assisted Ruthenium- and Rhodium-Catalyzed Couplings of α-Amino Acid Ester-Derived Phosphinamides with Alkynes

Two different types of new phosphinamide α-amino ester derivatives have been prepared in moderate to high yields via ruthenium(II) and rhodium(III)-catalyzed ortho-C?H functionalization under microwave irradiation. Specifically, the ortho-alkenylated phosphinamides were produced through coupling of phosphinamides containing an α-substituted or α,α-disubstituted α-amino ester with internal alkynes under ruthenium catalysis. In contrast, Ru and the more effective Rh-catalyzed coupling of the α-unsubstituted glycine ester phosphinamide with alkynes resulted in formation of oxidative annulation products, phosphaisoquinolin-1-ones. The developed methods feature the use of easily accessible starting materials, short reaction time, exclusive E-stereoselectivity (for ortho-alkenylation) and good functional group tolerance. The alkenylation reaction was readily scaled up to gram scale. Furthermore, the obtained alkenylated phosphinamide could be transformed into P-containing dipeptides through hydrolysis of the ester group in the catalysis product and subsequent condensation with an α-amino ester.

Copper mediated C(sp2)-H amination and hydroxylation of phosphinamides

Copper mediated C(sp2)-H amination and hydroxylation of arylphosphinic acid are accomplished by adopting phosphinamide as the directing group. This method is distinguished by its wide substrate scope and excellent functional group tolerance, th

Copper-Catalyzed Oxidative C(sp3)?H/N?H Cross-Coupling of Hydrocarbons with P(O)?NH Compounds: the Accelerating Effect Induced by Carboxylic Acid Coproduct

An chelation-assisted oxidative C(sp3)?H/N?H cross coupling of hydrocarbons with P(O)?NH compounds using copper acetate as catalyst is described. The results of kinetic experiments, mechanistic studies and DFT calculations demonstrate the importance of acetic acid coproduct as an additive for promoting the formation of intermediate bis((diphenylphosphoryl)(quinolin-8-yl)amino)copper (6), and consequently accelerating the construction of C(sp3)?N bond. The reaction proceeded efficiently with a wide array of hydrocarbons and P(O)?NH compounds, and the rate acceleration induced by the acetic acid coproduct have been repeatedly proven. Furthermore, the efficiency of small-scale reaction could be retained upon gram-scale synthesis in a continuous manner. (Figure presented.).