21014-26-6

Basic information

• Product Name: 2-Propenoic acid, 3-cyclopropyl-, ethyl ester, (2E)-
• CAS NO: 21014-26-6
• Molecular Formula: C8H12O2
• Molecular Weight: 140.182
• Mol File: 21014-26-6.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-cyclopropyl-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-cyclopropyl-, ethyl ester, (2E)-(21014-26-6)
• EPA Substance Registry System: 2-Propenoic acid, 3-cyclopropyl-, ethyl ester, (2E)-(21014-26-6)

Safety Data

• Hazardous Substances Data: 21014-26-6(Hazardous Substances Data)

Upstream product

• 70398-41-3 diethyl 2-(tetrahydrofuran-2-yl)malonate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1489-69-6 Cyclopropanecarboxaldehyde 
• 2516-33-8 Cyclopropylmethanol 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 1474-78-8 triethyl phosphonoformate 
• 17577-28-5 (ethoxycarbonylmethyl)triphenylphosphonium chloride 
• 22822-85-1 ethyl sodiodiethylphosphonoacetate 
• 17615-01-9 1-(triphenyl-λ⁵-phosphanylidene)pentan-2-one 

Downstream Products

• 60129-33-1 (trans)-3-cyclopropylacrylic acid 
• 158956-35-5 ((E)-3-Cyclopropyl-allyloxy)-diisopropyl-((E)-3-phenyl-allyloxy)-silane 

Relevant articles and documents

Synthesis of α,β-unsaturated esters from dialkoxyphosphoryl esters and aldehydes in the ionic liquid [bmim][PF6]

α,β-Unsaturated esters were synthesised by LiOH·H2O-promoted reactions of triethyl phosphonoacetate 1 and triethyl 3-methyl-4-phosphono-2-butenoate 2 with aldehydes in 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]).

Facile synthesis of α, β-unsaturated esters through a one-pot copper-catalyzed aerobic oxidation-Wittig reaction

An efficient one-pot synthesis of α, β-unsaturated esters through the aerobic oxidation – Wittig tandem reaction of alcohols and phosphorous ylide is developed. This new method operates under mild reaction conditions, and uses CuI/TEMPO (TEMPO = 2,2,6,6-tetramethylpiperidine-N-oxyl) as co-catalyst and air (O2) as the oxidant. It tolerates a wide range of functionalized benzylic alcohol and aliphatic alcohols.

CYCLOHEXYL GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES

Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: (Formula (I)) wherein R1, R2, R3, A, W, L, Ra, and G are defined herein: and by Formula (II) as follows: (Formula (II)) wherein R1B, WB, LB, and GB are defined herein.