210962-91-7

Basic information

• Product Name: METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE
• Synonyms: METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE;N-TBOC-P-IODO-D-PHENYLALANINE METHYL ESTER;Boc-4-iodo-D-phenylalanine methyl ester
• CAS NO: 210962-91-7
• Molecular Formula: C15H21ClINO4
• Molecular Weight: 441.69
• Mol File: 210962-91-7.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE(210962-91-7)
• EPA Substance Registry System: METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE(210962-91-7)

Safety Data

• Hazardous Substances Data: 210962-91-7(Hazardous Substances Data)

Usage

General Description

Methyl (R)-2-(tert-butoxycarbonylamino)-3-(4-iodophenyl)propanoate is a chemical compound with a molecular formula of C16H22INO4. It is a derivative of the amino acid leucine and is commonly used in the synthesis of peptide molecules. METHYL (R)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOATE is a white solid at room temperature and is insoluble in water but soluble in organic solvents. It is often used as a building block in the preparation of pharmaceuticals and research chemicals, and it is important for the development of new drugs and medications.

Upstream product

• 34619-03-9 tert-butyldicarbonate 
• 62561-75-5 (R)-2-amino-3-(4-iodophenyl)propanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1991-81-7 p-iodophenylalanine 
• 74-88-4 methyl iodide 
• 103882-09-3 N-Boc-DL-4-iodophenylalanine 
• 76757-90-9 N-(tert-butoxycarbonyl)-D-tyrosine methyl ester 
• 673-06-3 D-(R)-phenylalanine 
• 372967-43-6 (R)-methyl 2-amino-3-(4-iodophenyl)propanoate 
• 67-56-1 methanol 
• 1991-81-7 4-iodo-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 103882-09-3 N-Boc-4-I-Phe-OH 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 149818-98-4 methyl (R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanoate 
• 220587-29-1 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate 
• 137255-86-8 methyl (S)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate 
• 156017-43-5 (2S)-{4-[2-tert-butoxycarbonylamino-2-(methoxycarbonyl)-ethyl]-phenyl}difluoromethyl-phosphonic acid diethyl ester 
• 123993-30-6 (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid methylester 
• 850610-04-7 tert-butyl (S)-1-(methoxycarbonyl)-2-(4-(benzenesulfonyl)phenyl)ethylcarbamate 

Relevant articles and documents

Preparation method of sacubitril intermediate

The invention relates to the technical field of synthesis of medical intermediates, in particular to a preparation method of a sacubitril intermediate, which comprises the following steps: 1) reacting a raw material compound III with phosphorus trihalide to obtain a compound II; and 2) reacting the compound II with phenylhydrazine in the presence of a catalyst and an additive to obtain a sacubitril intermediate, namely a compound I. According to the invention, cheap phosphorus trihalide is selected to replace expensive and highly toxic trifluoromethanesulfonic anhydride, and cheap phenylhydrazine and a catalyst palladium chloride are adopted. The method has the advantages of simple reaction operation, low cost and high yield, and is easier for industrial production of the compound I.

Total Synthesis of Seongsanamide B

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Electrochemical synthesis of 1,2-diketones from alkynes under transition-metal-catalyst-free conditions

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