2110-78-3Relevant articles and documents
Palladium(II)-Catalyzed Cyclocarbonylation of Enol Ester of Acetone. A Novel Synthesis of 1,3-Dioxolan-4-one
Kudo, Kiyoshi,Mitsuhashi, Koichi,Mori, Sadayuki,Komatsu, Koichi,Sugita, Nobuyuki
, p. 1615 - 1618 (1993)
The cyclocarbonylation of isopropenyl acetate(1) to produce 2-methoxy-2,5,5-trimethyl-1,3-dioxolan-4-one(2) by use of palladium(II)-phoshine catalyst with methanol in benzene solution was studied at 100 degC under 200 atm of CO.Conversion of 1 up to 98percent and yield to 2 as high as 67percent were attained.
Flow-Assisted Synthesis: A Key Fragment of SR 142948A
Kitching, Matthew O.,Dixon, Olivia E.,Baumann, Marcus,Baxendale, Ian R.
, p. 6540 - 6553 (2017/09/13)
We report a series of multi-step flow operations to deliver an advanced hydrazine intermediate used in the assembly of the neurotensin modulator SR 142948A. Several new reactor configurations have enabled chemical transformations that would be otherwise difficult or dangerous to perform at scale. Overall the flow approach has allowed the preparation of kilogram quantities of the required hydrazine through a short and efficient route.
METHOD FOR PRODUCING ALPHA-HYDROXYCARBOXYLIC ACID ESTERS
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Paragraph 0080, (2014/05/20)
The present invention relates to a continuous process for preparing alpha-hydroxycarboxylic esters by reacting at least one alpha-hydroxycarboxamide present in the liquid phase with an alcohol in the presence of a catalyst, which is characterized in that the resulting alpha-hydroxycarboxylic ester is at least partly separated from the reaction mixture via the gas phase.