2115-91-5 Usage
Description
Dendrobine is a sesquiterpenoid alkaloid that has been isolated from the Dendrobium nobile plant. It is known to be an antagonist of β-alanine, taurine, and presynaptic inhibition in the frog spinal cord. Dendrobine exhibits anticancer activity and has been shown to decrease the viability of A549 cells at concentrations ranging from 2.5 to 15 μg/ml. It also induces apoptosis in A549 cells at concentrations between 1 to 10 μg/ml, increases JNK phosphorylation, and sensitizes A549 cells to cisplatin at 10 μg/ml. Furthermore, dendrobine (50 mg/kg per day) has been demonstrated to reduce tumor growth in an A549 mouse xenograft model, with an additive effect when used in combination with cisplatin.
Uses
Used in Anticancer Applications:
Dendrobine is used as an anticancer agent for its ability to decrease the viability of A549 cells and induce apoptosis at specific concentrations. It is particularly effective in targeting cancer cells and has shown potential in sensitizing cells to cisplatin, a commonly used chemotherapy drug.
Used in Drug Delivery Systems:
Dendrobine can be used as a component in drug delivery systems to enhance the efficacy of cancer treatments. Its ability to sensitize cancer cells to cisplatin suggests that it could be used in combination with other chemotherapeutic agents to improve their effectiveness and potentially reduce the required dosage, thereby minimizing side effects and improving patient outcomes.
Used in Pharmaceutical Research:
Dendrobine's antagonistic properties against β-alanine, taurine, and presynaptic inhibition in the frog spinal cord make it a valuable compound for further pharmaceutical research. Its unique characteristics may lead to the development of new drugs targeting various neurological conditions or as part of novel therapeutic strategies for cancer treatment.
Used in Natural Medicine:
As a compound derived from the Dendrobium nobile plant, dendrobine may also find applications in the field of natural medicine. Its potential anticancer properties and ability to induce apoptosis in cancer cells could make it a valuable addition to natural cancer treatment protocols, either as a standalone treatment or in combination with other natural compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 2115-91-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,1 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2115-91:
(6*2)+(5*1)+(4*1)+(3*5)+(2*9)+(1*1)=55
55 % 10 = 5
So 2115-91-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H25NO2/c1-8(2)11-12-10-6-5-9-7-17(4)14(16(9,10)3)13(11)19-15(12)18/h8-14H,5-7H2,1-4H3/t9?,10?,11?,12-,13-,14?,16?/m1/s1
2115-91-5Relevant articles and documents
Kende et al.
, p. 4332 (1974)
Total synthesis of (-)-dendrobine
Kreis, Lukas M.,Carreira, Erick M.
, p. 3436 - 3439 (2012/06/30)
Cascading to alkaloids: An 18-step total synthesis of (-)-dendrobine is based on a reaction cascade with a key amine group (see scheme, Bn=benzyl). The amine is the initiator of the cascade and provides an efficient method for installing the stereocenters at C11 and C3. The overall transformation occurs stereoselectively only when the conversion is carried out without the isolation of intermediates. Copyright
A short synthesis of (-)-dendrobine
Cassayare, Jér?me,Zard, Samir Z.
, p. 6072 - 6073 (2007/10/03)
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